The selection landscape and genetic legacy of ancient Eurasians.

Autor: Irving-Pease EK; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. evan.irvingpease@gmail.com., Refoyo-Martínez A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Barrie W; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Ingason A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark., Pearson A; Department of Genetics, University of Cambridge, Cambridge, UK.; Department of Zoology, University of Cambridge, Cambridge, UK., Fischer A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.; Sealand Archaeology, Kalundborg, Denmark., Sjögren KG; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Halgren AS; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA., Macleod R; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; UCL Genetics Institute, University College London, London, UK., Demeter F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Eco-anthropologie, Muséum national d'Histoire naturelle, CNRS, Université Paris Cité, Musée de l'Homme, Paris, France., Henriksen RA; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vimala T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., McColl H; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vaughn AH; Center for Computational Biology, University of California, Berkeley, CA, USA., Speidel L; UCL Genetics Institute, University College London, London, UK.; Ancient Genomics Laboratory, The Francis Crick Institute, London, UK., Stern AJ; Center for Computational Biology, University of California, Berkeley, CA, USA., Scorrano G; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Ramsøe A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Schork AJ; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark.; Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA., Rosengren A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark., Zhao L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Kristiansen K; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Iversen AKN; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Fugger L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.; MRC Human Immunology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK., Sudmant PH; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, CA, USA., Lawson DJ; Institute of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK., Durbin R; Department of Genetics, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Cambridge, UK., Korneliussen T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Werge T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct Hans, Copenhagen University Hospital, Copenhagen, Denmark., Allentoft ME; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Trace and Environmental DNA (TrEnD) Laboratory, School of Molecular and Life Science, Curtin University, Perth, Western Australia, Australia., Sikora M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Nielsen R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. rasmus_nielsen@berkeley.edu.; Departments of Integrative Biology and Statistics, UC Berkeley, Berkeley, CA, USA. rasmus_nielsen@berkeley.edu., Racimo F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. fracimo@sund.ku.dk., Willerslev E; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. ew482@cam.ac.uk.; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK. ew482@cam.ac.uk.; MARUM Center for Marine Environmental Sciences and Faculty of Geosciences, University of Bremen, Bremen, Germany. ew482@cam.ac.uk.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Jan; Vol. 625 (7994), pp. 312-320. Date of Electronic Publication: 2024 Jan 10.
DOI: 10.1038/s41586-023-06705-1
Abstrakt: The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes 1 , we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer's disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.
(© 2024. The Author(s).)
Databáze: MEDLINE
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