Comparison of the Alinity M STI with the GeneXpert CT/NG for the detection of sexually transmitted microorganisms.

Autor: Farfour E; Service de biologie Clinique, hôpital Foch, Suresnes, France. Electronic address: ericf6598@yahoo.fr., Kitous C; Service de biologie Clinique, hôpital Foch, Suresnes, France., Zucman D; Réseau Ville-Hôpital, Service de médecine interne, Hôpital Foch, Suresnes, France., Touche P; Délégation à la recherche clinique et à l'innovation, Hôpital Foch, Suresnes, France., Panel K; Délégation à la recherche clinique et à l'innovation, Hôpital Foch, Suresnes, France., Fourn E; Réseau Ville-Hôpital, Service de médecine interne, Hôpital Foch, Suresnes, France., Vasse M; Service de biologie Clinique, hôpital Foch, Suresnes, France; Université Paris-Saclay, INSERM Hémostase inflammation thrombose HITH U1176, 94276 Le Kremlin-Bicêtre, France.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Mar; Vol. 108 (3), pp. 116179. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1016/j.diagmicrobio.2024.116179
Abstrakt: We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), and both micro-organisms respectively. The Alinity M STI and the Xpert CT/NG results were in accordance for all. The mean difference in cycle threshold values between the Xpert CT/NG and the Alinity M STI were -1.6 and 0.0 for CT and NG respectively. Then 214 fresh samples collected from 121 patients were prospectively tested with both instruments. Anal swabs, throat swabs, vaginal swabs, and urines accounted each for about 25%. Seven (3.2%) samples of which 5 anal swabs, provided inconclusive results with the Alinity M STI. In conclusion, the Alinity M STI is an accurate device for the microbiological diagnosis of NG and CT infections.
Competing Interests: Declaration of competing interest The authors declare there are no competing interests.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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