Comparison of two methods simulating inter-track interactions using the radiobiological Monte Carlo toolkit TOPAS-nBio.

Autor: Derksen L; University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany., Adeberg S; Marburg University Hospital, Department of Radiotherapy and Radiation Oncology, Marburg, Germany.; Marburg Ion-Beam Therapy Center (MIT), Department of Radiotherapy and Radiation Oncology, Marburg University Hospital, Marburg, Germany.; University Cancer Center, Frankfurt-Marburg, Germany., Zink K; University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany.; Marburg University Hospital, Department of Radiotherapy and Radiation Oncology, Marburg, Germany.; Marburg Ion-Beam Therapy Center (MIT), Department of Radiotherapy and Radiation Oncology, Marburg University Hospital, Marburg, Germany., Baumann KS; University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany.; Marburg University Hospital, Department of Radiotherapy and Radiation Oncology, Marburg, Germany.; Marburg Ion-Beam Therapy Center (MIT), Department of Radiotherapy and Radiation Oncology, Marburg University Hospital, Marburg, Germany.
Jazyk: angličtina
Zdroj: Physics in medicine and biology [Phys Med Biol] 2024 Jan 24; Vol. 69 (3). Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1088/1361-6560/ad1cf4
Abstrakt: Objective. To compare two independently developed methods that enable modelling inter-track interactions in TOPAS-nBio by examining the yield of radiolytic species in radiobiological Monte Carlo track structure simulations. One method uses a phase space file to assign more than one primary to one event, allowing for inter-track interaction between these primary particles. This method has previously been developed by this working group and published earlier. Using the other method, chemical reactions are simulated based on a new version of the independent reaction time approach to allow inter-track interactions. Approach. G -values were calculated and compared using both methods for different numbers of tracks able to undergo inter-track interactions. Main results. Differences in the G -values simulated with the two methods strongly depend on the molecule type, and deviations can range up to 3.9% (H 2 O 2 ), although, on average, the deviations are smaller than 1.5%. Significance. Both methods seem to be suitable for simulating inter-track interactions, as they provide comparable G -values even though both techniques were developed independently of each other.
(Creative Commons Attribution license.)
Databáze: MEDLINE
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