Comparison of tracer kinetic models for 68 Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients.

Autor: Smith NJ; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA. smithnaj@iu.edu.; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. smithnaj@iu.edu., Green MA; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA., Bahler CD; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA., Tann M; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA., Territo W; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA., Smith AM; Siemens Medical Solutions USA, Inc., Knoxville, TN, USA., Hutchins GD; Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN, 46202, USA.
Jazyk: angličtina
Zdroj: EJNMMI research [EJNMMI Res] 2024 Jan 10; Vol. 14 (1), pp. 6. Date of Electronic Publication: 2024 Jan 10.
DOI: 10.1186/s13550-023-01066-2
Abstrakt: Background: 68 Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified as standard uptake values (SUVs) for clinical decision-making. However, analysis of dynamic images characterizing both tracer uptake and pharmacokinetics may offer added insights into the underlying tissue pathophysiology. This study was undertaken to evaluate the suitability of various kinetic models for 68 Ga-PSMA-11 PET analysis. Twenty-three lesions in 18 patients were included in a retrospective kinetic evaluation of 55-min dynamic 68 Ga-PSMA-11 pre-prostatectomy PET scans from patients with biopsy-demonstrated intermediate- to high-risk prostate cancer. Three kinetic models-a reversible one-tissue compartment model, an irreversible two-tissue compartment model, and a reversible two-tissue compartment model, were evaluated for their goodness of fit to lesion and normal reference prostate time-activity curves. Kinetic parameters obtained through graphical analysis and tracer kinetic modeling techniques were compared for reference prostate tissue and lesion regions of interest.
Results: Supported by goodness of fit and information loss criteria, the irreversible two-tissue compartment model optimally fit the time-activity curves. Lesions exhibited significant differences in kinetic rate constants (K 1 , k 2 , k 3 , K i ) and semiquantitative measures (SUV and %ID/kg) when compared with reference prostatic tissue. The two-tissue irreversible tracer kinetic model was consistently appropriate across prostatic zones.
Conclusions: An irreversible tracer kinetic model is appropriate for dynamic analysis of 68 Ga-PSMA-11 PET images. Kinetic parameters estimated by Patlak graphical analysis or full compartmental analysis can distinguish tumor from normal prostate tissue.
(© 2024. The Author(s).)
Databáze: MEDLINE
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