Facile synthesis of N -(α-furanyl) alkyl sulfoximines via gold catalyzed Michael addition/cyclization of enynones and sulfoximines.

Autor:	Antony Haritha Mercy A; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Padma Priya VR; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Hariprasad R; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Gayathri K; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Ravindra S; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Chandra Nandi G; Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, Tamil Nadu, India. ganeshnandi@gmail.com., Kataria R; Department of Chemistry, Panjab University, Chandigarh, 160014, India.
Jazyk:	angličtina
Zdroj:	Organic & biomolecular chemistry [Org Biomol Chem] 2024 Jan 31; Vol. 22 (5), pp. 945-949. Date of Electronic Publication: 2024 Jan 31.
DOI:	10.1039/d3ob01631e
Abstrakt:	Herein, we prepare a new array of N -(α-furanyl) alkyl sulfoximines via a gold catalyzed reaction of enynone with sulfoximine in moderate to very good yields. The reaction involves Michael addition of sulfoximine to enynone, followed by intramolecular cyclization. The presence of two chiral centres led to the formation of a mixture of diastereomers approximately in a 1 : 1 ratio. The salient features of the protocol include broad substrate scope, high efficiency and high yields. The synthetic utility of the protocol is explored using Suzuki-Miyaura cross-coupling and mild, metal-free opening of the furan ring.
Databáze:	MEDLINE
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