Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor.

Autor: Cataldo AVR; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Collimore AN; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Spangler J; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Ribeirinha-Braga L; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Hutchinson K; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Wang QM; Spaulding Rehabilitation Hospital Charlestown MA 02129 USA., Thompson L; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA., Awad LN; Boston University, College of Health and Rehabilitation Sciences: Sargent Boston MA 02215 USA.
Jazyk: angličtina
Zdroj: IEEE open journal of engineering in medicine and biology [IEEE Open J Eng Med Biol] 2023 Sep 08; Vol. 4, pp. 284-291. Date of Electronic Publication: 2023 Sep 08 (Print Publication: 2023).
DOI: 10.1109/OJEMB.2023.3313396
Abstrakt: Objective: High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher intensities and longer durations, resulting in a corresponding increase in circulating brain-derived neurotrophic factor (BDNF). Results: Eleven individuals >6-mo post-stroke completed a two-session, pilot randomized crossover trial (NCT05138016). Maximum training speed (Δ: 0.07 ± 0.03 m/s), duration (Δ: 2.07 ± 0.88 min), and intensity (VO 2 peak, Δ: 1.75 ± 0.60 ml-O 2 /kg/min) significantly increased (p < 0.05) during exosuit-augmented training compared to no-exosuit training. Post-session increases in BDNF (Δ: 5.96 ± 2.27 ng/ml, p = 0.03) were observed only after exosuit-augmented training. Biomechanical changes were not observed after exosuit-augmented training; however, a deterioration in gait propulsion symmetry (%Δ: -5 ± 2 %) and an increase in nonparetic propulsion (Δ: 0.9 ± 0.3 %bw) were observed (p < 0.05) after no-exosuit training. Conclusion: Soft robotic exosuits facilitate faster, longer duration, and higher intensity walking training associated with enhanced neuroplasticity.
(© 2023 The Authors.)
Databáze: MEDLINE
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