The effects of injectable platelet-rich fibrin application on wound healing following gingivectomy and gingivoplasty operations: single-blind, randomized controlled, prospective clinical study.

Autor: Bahar ŞÇ; Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Neighborhood of Emrah, Keçiören, Ankara, Turkey. seyma931993@gmail.com., Karakan NC; Department of Periodontology, Faculty of Dentistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey., Vurmaz A; Department of Biochemistry, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Jan 10; Vol. 28 (1), pp. 85. Date of Electronic Publication: 2024 Jan 10.
DOI: 10.1007/s00784-023-05477-2
Abstrakt: Objectives: The aim of this study was to evaluate the effects of wound healing using injectable platelet-rich fibrin (IPRF) after gingivectomy and gingivoplasty.
Materials and Methods: In this clinical study, 46 systemically healthy patients with chronic inflammatory gingival enlargement were randomly treated with gingivectomy-gingivoplasty + I-PRF (n=23) or gingivectomy-gingivoplasty alone (n=23). The primary outcome was to evaluate the effect of I-PRF on wound healing over a 3-week follow-up period. Samples collected from gingival crevicular fluid (GCF) were processed using enzyme-linked immunosorbent assay (ELİSA) to measure VEGF and FGF-10 biomarkers. The surgical areas were stained with Mira-2 tone and evaluated in ImageJ. Wound healing was evaluated with Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index.
Results: VEGF values of the control group at baseline, week 2, and week 3 were significantly higher than the test group. In weeks 2 and 3, FGF-10 values were found to be significantly higher in the control group than the test group. The amount of staining was found to be significantly higher in the control group than in the test group on days 3, 7, and 14. LTH values of the control group were significantly lower than the test group and MMS values were significantly higher than those of the test group.
Conclusions: I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
Clinical Relevance: Platelet concentrates such as I-PRF accelerate wound healing and contribute to the patient's comfort and quality of life. I-PRF application may have positive effects on wound healing after gingivectomy and gingivoplasty operations.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: