Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson's disease.

Autor:	Olaru M; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., Cernera S; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., Hahn A; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., Wozny TA; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., Anso J; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., de Hemptinne C; Department of Neurology, University of Florida Gainesville, Gainesville, FL 32611, USA., Little S; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA., Neumann WJ; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany., Abbasi-Asl R; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA., Starr PA; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2024 Jun 03; Vol. 147 (6), pp. 2038-2052.
DOI:	10.1093/brain/awae004
Abstrakt:	In Parkinson's disease, imbalances between 'antikinetic' and 'prokinetic' patterns of neuronal oscillatory activity are related to motor dysfunction. Invasive brain recordings from the motor network have suggested that medical or surgical therapy can promote a prokinetic state by inducing narrowband gamma rhythms (65-90 Hz). Excessive narrowband gamma in the motor cortex promotes dyskinesia in rodent models, but the relationship between narrowband gamma and dyskinesia in humans has not been well established. To assess this relationship, we used a sensing-enabled deep brain stimulator system, attached to both motor cortex and basal ganglia (subthalamic or pallidal) leads, paired with wearable devices that continuously tracked motor signs in the contralateral upper limbs. We recorded 984 h of multisite field potentials in 30 hemispheres of 16 subjects with Parkinson's disease (2/16 female, mean age 57 ± 12 years) while at home on usual antiparkinsonian medications. Recordings were done 2-4 weeks after implantation, prior to starting therapeutic stimulation. Narrowband gamma was detected in the precentral gyrus, subthalamic nucleus or both structures on at least one side of 92% of subjects with a clinical history of dyskinesia. Narrowband gamma was not detected in the globus pallidus. Narrowband gamma spectral power in both structures co-fluctuated similarly with contralateral wearable dyskinesia scores (mean correlation coefficient of ρ = 0.48 with a range of 0.12-0.82 for cortex, ρ = 0.53 with a range of 0.5-0.77 for subthalamic nucleus). Stratification analysis showed the correlations were not driven by outlier values, and narrowband gamma could distinguish 'on' periods with dyskinesia from 'on' periods without dyskinesia. Time lag comparisons confirmed that gamma oscillations herald dyskinesia onset without a time lag in either structure when using 2-min epochs. A linear model incorporating the three oscillatory bands (beta, theta/alpha and narrowband gamma) increased the predictive power of dyskinesia for several subject hemispheres. We further identified spectrally distinct oscillations in the low gamma range (40-60 Hz) in three subjects, but the relationship of low gamma oscillations to dyskinesia was variable. Our findings support the hypothesis that excessive oscillatory activity at 65-90 Hz in the motor network tracks with dyskinesia similarly across both structures, without a detectable time lag. This rhythm may serve as a promising control signal for closed-loop deep brain stimulation using either cortical or subthalamic detection. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu