Pyrimido[5,4-c]quinolines: Synthesis from 3,4-Di-functionallized Quinoline, Reactivity and Biological Activities.

Autor: Gouda MA; Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia.; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt., Abu-Hashem AA; Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jazan, 45142, Saudi Arabia.; Photochemistry Department (Heterocyclic Unit), National Research Centre, 12622 Dokki, Giza, Egypt., Ameen TA; Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jazan, 45142, Saudi Arabia., Althagafi SH; Department of Chemistry, Faculty of Science, Albaha University, P.O.Box 1988, Albaha, 65799, Saudi Arabia., Hamama WS; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt., Khalil AM; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Mar; Vol. 21 (3), pp. e202301968. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.1002/cbdv.202301968
Abstrakt: Quinoline and pyrimidine moieties are ubiquitous components in both natural and synthetic compounds, showcasing diverse applications. The fusion of these well-known structures into hybrid molecules has garnered attention due to their intriguing biological properties. Particularly in the field of medicinal chemistry, numerous studies in the last decade have focused on pyrimido[5,4-c]quinoline ring systems (PyQs5,4-c). This review elucidates the synthesis of PyQs5,4-c and their derivatives using 3,4-difunctionalized quinoline as a key starting material. The preparation of PyQs5,4-c involves a series of chemical transformations, including the Friedländer, Ullmann and Biginelli reaction, Vilsmeier-Haack formylation, Suzuki coupling, and a one-pot three-component reaction. These synthetic routes not only offer access to diverse PyQs5,4-c derivatives.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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