Effects of Physical Exercise on Telomere Length in Healthy Adults: Systematic Review, Meta-Analysis, and Meta-Regression.

Autor:	Sánchez-González JL; Faculty of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain., Sánchez-Rodríguez JL; Department of Basic Psychology, Psychobiology and Methodology, Faculty of Psychology, University of Salamanca, Salamanca, Spain., Varela-Rodríguez S; Faculty of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain., González-Sarmiento R; Molecular Medicine Unit, Instituto de Investigación Biomédica de Salamanca, University of Salamanca-Sanidad de Castilla y León - Consejo Superior de Investigaciones Científicas, Salamanca, Spain., Rivera-Picón C; Faculty of Health Sciences, Nursing, Pontifical University of Salamanca, Salamanca, Spain., Juárez-Vela R; Nursing Department, Faculty of Heatlh Sciences, University of La Rioja, Logroño, Spain., Tejada-Garrido CI; Nursing Department, Faculty of Heatlh Sciences, University of La Rioja, Logroño, Spain., Martín-Vallejo J; Departament of Stadístics, Faculty of Medicine, University of Salamanca, Salamanca, Spain., Navarro-López V; Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	JMIR public health and surveillance [JMIR Public Health Surveill] 2024 Jan 09; Vol. 10, pp. e46019. Date of Electronic Publication: 2024 Jan 09.
DOI:	10.2196/46019
Abstrakt:	Background: Physical exercise is one of the main nonpharmacological treatments for most pathologies. In addition, physical exercise is beneficial in the prevention of various diseases. The impact of physical exercise has been widely studied; however, existing meta-analyses have included diverse and heterogeneous samples. Therefore, to our knowledge, this is the first meta-analysis to evaluate the impact of different physical exercise modalities on telomere length in healthy populations. Objective: In this review, we aimed to determine the effect of physical exercise on telomere length in a healthy population through a meta-analysis of randomized controlled trials. Methods: A systematic review with meta-analysis and meta-regression of the published literature on the impact of physical exercise on telomere length in a healthy population was performed. PubMed, Cochrane Library, SCOPUS, Web of Science, and Embase databases were searched for eligible studies. Methodological quality was evaluated using the Risk Of Bias In Nonrandomized Studies of Interventions and the risk-of-bias tool for randomized trials. Finally, the certainty of our findings (closeness of the estimated effect to the true effect) was evaluated using Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Results: We included 9 trials that met the inclusion criteria with fair methodological quality. Random-effects model analysis was used to quantify the difference in telomere length between the exercise and sham groups. Meta-analysis showed that exercise did not significantly increase telomere length compared with the control intervention (mean difference=0.0058, 95% CI -0.05 to 0.06; P=.83). Subgroup analysis suggested that high-intensity interventional exercise significantly increased telomere length compared with the control intervention in healthy individuals (mean difference=0.15, 95% CI 0.03-0.26; P=.01). Furthermore, 56% of the studies had a high risk of bias. Certainty was graded from low to very low for most of the outcomes. Conclusions: The findings of this systematic review and meta-analysis suggest that high-intensity interval training seems to have a positive effect on telomere length compared with other types of exercise such as resistance training or aerobic exercise in a healthy population. Trial Registration: PROSPERO CRD42022364518; http://tinyurl.com/4fwb85ff. (©Juan Luis Sánchez-González, Juan Luis Sánchez-Rodríguez, Sergio Varela-Rodríguez, Rogelio González-Sarmiento, Cristina Rivera-Picón, Raúl Juárez-Vela, Clara Isabel Tejada-Garrido, Javier Martín-Vallejo, Víctor Navarro-López. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 09.01.2024.)
Databáze:	MEDLINE
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