The Influence of Adiponectin on Transport of Low-Density Lipoproteins through Human Endothelial Cell Monolayer In Vitro.

Autor: Tanyanskiy DA; Institute of Experimental Medicine, St. Petersburg, Russia. dmitry.athero@gmail.com., Maltseva ON; Institute of Experimental Medicine, St. Petersburg, Russia., Trulioff AS; Institute of Experimental Medicine, St. Petersburg, Russia., Saginbaev UR; Institute of Experimental Medicine, St. Petersburg, Russia., Evstigneeva PE; Institute of Experimental Medicine, St. Petersburg, Russia., Voronkina IV; Institute of Experimental Medicine, St. Petersburg, Russia., Smagina LV; Institute of Experimental Medicine, St. Petersburg, Russia., Ivanova AA; Institute of Experimental Medicine, St. Petersburg, Russia., Dmitrieva AA; Institute of Experimental Medicine, St. Petersburg, Russia., Ageeva EV; Institute of Experimental Medicine, St. Petersburg, Russia., Sall TS; Institute of Experimental Medicine, St. Petersburg, Russia., Denisenko AD; Institute of Experimental Medicine, St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Dec; Vol. 176 (2), pp. 165-169. Date of Electronic Publication: 2024 Jan 09.
DOI: 10.1007/s10517-024-05988-2
Abstrakt: The influence of adiponectin, a protein secreted by adipocytes, on the activation of transendothelial LDL transport, the initial event of atherogenesis, was studied. The addition of adiponectin to the cultured endothelial hybridoma EA.hy926 cells did not affect both basal and TNF-stimulated transendothelial transport of LDL. In addition, adiponectin affects neither expression levels of CAV1, SCARB1, and ACVRL1 genes encoding proteins involved in transendothelial LDL transport, nor the MMP secretion by the EA.hy926cells. At the same time, adiponectin suppressed the TNF-stimulated IL-8 production and expression of the adhesion molecule gene ICAM1 in these cells. Thus, adiponectin reduces proinflammatory activation of EA.hy926 cells, which is not accompanied by changes in the transendothelial LDL transport. We speculate that anti-inflammatory action of adiponectin is the base for the influence of this adipokine on atherogenesis.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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