Microbiome signatures in ischemic stroke: A systematic review.

Autor:	Zhang W; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.; The School of Stomatology, Lanzhou University, Lanzhou, China.; Healthy Examination & Management Center of Lanzhou University Second Hospital, Lanzhou, China., Tang R; The School of Stomatology, Lanzhou University, Lanzhou, China., Yin Y; Healthy Examination & Management Center of Lanzhou University Second Hospital, Lanzhou, China., Chen J; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Yao L; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.; Department of Neurology, Lanzhou University First Hospital, Lanzhou, China., Liu B; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.; The School of Stomatology, Lanzhou University, Lanzhou, China.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Dec 16; Vol. 10 (1), pp. e23743. Date of Electronic Publication: 2023 Dec 16 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2023.e23743
Abstrakt:	Microbial structural changes and dysfunction play an important role in the development of cerebral ischemia. We searched PubMed, Embase, Web of Science, and Cochrane Library and conducted a systematic review to assess the relationship between the human microbiome and ischemic stroke. A total of 24 studies were included, and the intestinal bacterial communities detected in both stroke and healthy people were dominated by 4 main phyla, including Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Significant diversity (alpha and beta) in patients with ischemic versus nonischemic stroke was observed in nine out of 18 studies, and 3 studies showed that the severity of ischemic stroke affected microbial diversity. The imbalance of bacteria that produce short-chain fatty acids (SCFAs) changes the bacterial metabolic pathway, and disorders in the level of bacterial metabolites (trimethylamine N-oxide TMAO) lead to significant changes in intestinal flora function, which may aggravate the severity of stroke and affect its prognosis. Further studies are needed to explore the relationship between the microbiome and ischemic stroke. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu