Experience shapes chandelier cell function and structure in the visual cortex.
Autor: | Seignette K; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Jamann N; Department of Axonal Signaling, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Department of Biology Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, Netherlands., Papale P; Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Terra H; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Porneso RO; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., de Kraker L; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., van der Togt C; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., van der Aa M; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Neering P; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Ruimschotel E; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Roelfsema PR; Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Laboratory of Visual Brain Therapy, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris, France.; Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, VU University, Amsterdam, Netherlands.; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Montijn JS; Department of Cortical Structure & Function, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Self MW; Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Kole MHP; Department of Axonal Signaling, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Department of Biology Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, Netherlands., Levelt CN; Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands. |
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Jazyk: | angličtina |
Zdroj: | ELife [Elife] 2024 Jan 09; Vol. 12. Date of Electronic Publication: 2024 Jan 09. |
DOI: | 10.7554/eLife.91153 |
Abstrakt: | Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we found that V1 ChCs predominantly receive monosynaptic input from local layer 5 pyramidal cells and higher-order cortical regions. Two-photon calcium imaging and convolutional neural network modeling revealed that ChCs are visually responsive but weakly selective for stimulus content. In mice running in a virtual tunnel, ChCs respond strongly to events known to elicit arousal, including locomotion and visuomotor mismatch. Repeated exposure of the mice to the virtual tunnel was accompanied by reduced visual responses of ChCs and structural plasticity of ChC boutons and axon initial segment length. Finally, ChCs only weakly inhibited pyramidal cells. These findings suggest that ChCs provide an arousal-related signal to layer 2/3 pyramidal cells that may modulate their activity and/or gate plasticity of their axon initial segments during behaviorally relevant events. Competing Interests: KS, NJ, PP, HT, RP, Ld, Cv, Mv, PN, ER, PR, JM, MS, MK, CL No competing interests declared (© 2023, Seignette et al.) |
Databáze: | MEDLINE |
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