Hemodynamics of Saline Flushing in Endoscopic Imaging of Partially Occluded Coronary Arteries.

Autor: Faisal S; Mechanical Engineering Department, University of Washington, Seattle, WA, USA., Barbour M; Mechanical Engineering Department, University of Washington, Seattle, WA, USA. barbourm@u.washington.edu., Seibel EJ; Mechanical Engineering Department, University of Washington, Seattle, WA, USA., Aliseda A; Mechanical Engineering Department, University of Washington, Seattle, WA, USA.
Jazyk: angličtina
Zdroj: Cardiovascular engineering and technology [Cardiovasc Eng Technol] 2024 Apr; Vol. 15 (2), pp. 211-223. Date of Electronic Publication: 2024 Jan 08.
DOI: 10.1007/s13239-023-00708-9
Abstrakt: Purpose: Intravascular endoscopy can aid in the diagnosis of coronary atherosclerosis by providing direct color images of coronary plaques. The procedure requires a blood-free optical path between the catheter and plaque, and achieving clearance safely remains an engineering challenge. In this study, we investigate the hemodynamics of saline flushing in partially occluded coronary arteries to advance the development of intravascular forward-imaging catheters that do not require balloon occlusion.
Methods: In-vitro experiments and CFD simulations are used to quantify the influence of plaque size, catheter stand-off distance, saline injection flowrate, and injection orientation on the time required to achieve blood clearance.
Results: Experiments and simulation of saline injection from a dual-lumen catheter demonstrated that flushing times increase both as injection flow rate (Reynolds number) decreases and as the catheter moves distally away from the plaque. CFD simulations demonstrated that successful flushing was achieved regardless of lumen axial orientation in a 95% occluded artery. Flushing time was also found to increase as plaque size decreases for a set injection flowrate, and a lower limit for injection flowrate was found to exist for each plaques size, below which clearance was not achieved. For the three occlusion sizes investigated (90, 95, 97% by area), successful occlusion was achieved in less than 1.2 s. Investigation of the pressure fields developed during injection, highlight that rapid clearance can be achieved while keeping the arterial overpressure to < 1 mmHg.
Conclusions: A dual lumen saline injection catheter was shown to produce clearance safely and effectively in models of partially occluded coronary arteries. Clearance was achieved across a range of engineering and clinical parameters without the use of a balloon occlusion, providing development guideposts for a fluid injection system in forward-imaging coronary endoscopes.
(© 2024. The Author(s) under exclusive licence to Biomedical Engineering Society.)
Databáze: MEDLINE
Externí odkaz: