Long-term application of adrenergic agonists modulates nociceptive ion channels.

Autor: Medrado AS; Department of Physiology and Biophysics, Institute of Biological Sciences-ICB, Federal University of Minas Gerais-UFMG., Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Zip-code: 31270-901, Brazil., Santiago NAS; Department of Physiology and Biophysics, Institute of Biological Sciences-ICB, Federal University of Minas Gerais-UFMG., Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Zip-code: 31270-901, Brazil., Moraes ER; Department of Physiology and Biophysics, Institute of Biological Sciences-ICB, Federal University of Minas Gerais-UFMG., Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Zip-code: 31270-901, Brazil. Electronic address: ermoraes79@gmail.com., Kushmerick C; Department of Physiology and Biophysics, Institute of Biological Sciences-ICB, Federal University of Minas Gerais-UFMG., Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Zip-code: 31270-901, Brazil., Naves LA; Department of Physiology and Biophysics, Institute of Biological Sciences-ICB, Federal University of Minas Gerais-UFMG., Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Zip-code: 31270-901, Brazil.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2024 Feb 06; Vol. 822, pp. 137628. Date of Electronic Publication: 2024 Jan 06.
DOI: 10.1016/j.neulet.2024.137628
Abstrakt: Dorsal root ganglia (DRG) neurons transduce and convey somatosensory information from the periphery to the central nervous system. Adrenergic mediators are known to modulate nociceptive inputs in DRG neurons, acting as up- or down-regulators of neuronal excitability. They are also important in the development of sympathetic neuropathy. ATP-activated P2X channels and capsaicin-activated TRPV1 channels are directly involved in the transduction of nociceptive stimuli. In this work, we show that long-term (up to 3 days) in vitro stimulation of DRG neurons with selective α1-adrenergic agonist increased slow but not fast ATP-activated currents, with no effect on capsaicin currents. Selective agonists for α2, β1 and β3-adrenergic receptors decreased capsaicin activated currents and had no effect on ATP currents. Capsaicin currents were associated with increased neuronal excitability, while none of the adrenergic modulators produced change in rheobase. These results demonstrate that chronic adrenergic activation modulates two nociceptive transducer molecules, increasing or decreasing channel current depending on the adrenergic receptor subtype. These observations aid our understanding of nociceptive or antinociceptive effects of adrenergic agonists.
Competing Interests: Declaration of competing interest The authors Aline S. Medrado, Naiara A. S. Santiago, Eder R. Moraes, Christopher Kushmerick, and Lígia A. Naves declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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