Features of α 2 -Adrenergic Regulation of Isolated Rat Heart after Hypokinesia.

Autor: Sungatullina MI; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Zaripova RI; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Mosolov LT; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Sadykov AM; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Ziyatdinova NI; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia., Zefirov TL; Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia. zefirovtl@mail.ru.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Dec; Vol. 176 (2), pp. 156-159. Date of Electronic Publication: 2024 Jan 08.
DOI: 10.1007/s10517-024-05986-4
Abstrakt: We studied the effect of the α 2 -adrenergic receptor agonist clonidine hydrochloride (10 -9 -10 -6 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison with control animals, clonidine caused a positive inotropic effect; the dynamics of coronary flow was changed after stimulation of α 2 -adrenergic receptors by clonidine in the minimum and maximum concentrations. Moreover, clonidine in concentrations of 10 -8 and 10 -7 M reduced coronary flow both in the control group and against the background of hypokinesia. Clonidine (10 -8 -10 -6 M) had a negative chronotropic effect in control and hypokinetic animals, while the dynamics of HR was multidirectional, i.e. either an increase or decrease in the effects was observed depending of the agonist concentration. Overall, the data obtained indicate the participation of α 2 -adrenergic receptors in adaptive processes after motor activity limitation.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: