Correlation Between Insulin Resistance and Urinary Incontinence in Female Patients with Type 2 Diabetes Mellitus.

Autor: Li S; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China., Zou J; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China., Wang Z; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China., Wang M; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China., Yuan Y; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China., Lv H; Department of Endocrinology, The First Hospital of Lanzhou University, 1 Donggang West Road, Lanzhou, 730000, Gansu, China. lvhh@lzu.edu.cn.
Jazyk: angličtina
Zdroj: International urogynecology journal [Int Urogynecol J] 2024 Feb; Vol. 35 (2), pp. 431-440. Date of Electronic Publication: 2024 Jan 08.
DOI: 10.1007/s00192-023-05715-x
Abstrakt: Introduction and Hypothesis: Patients with type 2 diabetes mellitus (T2DM) are at a high risk of developing urinary incontinence; however, its pathogenesis is unclear. The purpose of this study is to explore the relationship between insulin resistance and urinary incontinence and its severity in female patients with T2DM.
Methods: A total of 366 women with T2DM aged ≥18 years were enrolled in this study. Insulin resistance was evaluated by the homeostasis model insulin resistance (HOMA-IR) index and urinary incontinence was assessed by the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF). All subjects were divided into four groups according to HOMA-IR quartiles. Logistic regression analysis was performed to investigate the relationship between insulin resistance and urinary incontinence and its severity.
Results: Among the 366 patients, 186 (50.8%) had urinary incontinence. The prevalence of urinary incontinence increased significantly with HOMA-IR quartiles (p < 0.001). Adjusted logistic regression analysis showed that compared with HOMA-IR ≤ 1.76, 2.81 ≤ HOMA-IR ≤ 4.27 was associated with a significantly increased risk of moderate incontinence (OR = 2.197, 95% CI 1.031-4.683, p = 0.041), and HOMA-IR ≥ 4.28 was associated with a significantly increased risk of severe incontinence (OR = 5.699, 95% CI 1.685-19.276, p = 0.005). Binary logistic regression analysis showed that HOMA-IR was the independent risk factor for urinary incontinence (p < 0.001).
Conclusions: Higher levels of insulin resistance are associated with urinary incontinence and its severity in female patients with type 2 diabetes mellitus.
(© 2024. The International Urogynecological Association.)
Databáze: MEDLINE
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