Metabolites in the regulatory risk assessment of pesticides in the EU.

Autor:	Pelkonen O; Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Oulu, Finland., Abass K; Department of Environmental Health Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Sharjah Institute for Medical Research (SIMR), University of Sharjah, Sharjah, United Arab Emirates.; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland., Parra Morte JM; EFSA, European Food Safety Authority, Parma, Italy., Panzarea M; EFSA, European Food Safety Authority, Parma, Italy., Testai E; Mechanisms, Biomarkers and Models Unit, Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy., Rudaz S; School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland., Louisse J; EFSA, European Food Safety Authority, Parma, Italy.; Wageningen Food Safety Research (WFSR), Wageningen, Netherlands., Gundert-Remy U; Institute of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Wolterink G; Centre for Prevention, Lifestyle and Health, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Jean-Lou Cm D; EFSA, European Food Safety Authority, Parma, Italy., Coecke S; European Commission, Joint Research Centre (JRC), Ispra, Italy., Bernasconi C; European Commission, Joint Research Centre (JRC), Ispra, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in toxicology [Front Toxicol] 2023 Dec 19; Vol. 5, pp. 1304885. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
DOI:	10.3389/ftox.2023.1304885
Abstrakt:	A large majority of chemicals is converted into metabolites through xenobiotic-metabolising enzymes. Metabolites may present a spectrum of characteristics varying from similar to vastly different compared with the parent compound in terms of both toxicokinetics and toxicodynamics. In the pesticide arena, the role of metabolism and metabolites is increasingly recognised as a significant factor particularly for the design and interpretation of mammalian toxicological studies and in the toxicity assessment of pesticide/metabolite-associated issues for hazard characterization and risk assessment purposes, including the role of metabolites as parts in various residues in ecotoxicological adversities. This is of particular relevance to pesticide metabolites that are unique to humans in comparison with metabolites found in in vitro or in vivo animal studies, but also to disproportionate metabolites (quantitative differences) between humans and mammalian species. Presence of unique or disproportionate metabolites may underlie potential toxicological concerns. This review aims to present the current state-of-the-art of comparative metabolism and metabolites in pesticide research for hazard and risk assessment, including One Health perspectives, and future research needs based on the experiences gained at the European Food Safety Authority. Competing Interests: JoL, JeL, MP and JP were employed by the European Food Safety Authority (EFSA). SC and CB were employed by the European Commission Joint Research Centre (JRC). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2023 Pelkonen, Abass, Parra Morte, Panzarea, Testai, Rudaz, Louisse, Gundert-Remy, Wolterink, Jean-Lou CM, Coecke and Bernasconi.)
Databáze:	MEDLINE
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