Closed-loop microstimulations of the orbitofrontal cortex during real-life gaze interaction enhance dynamic social attention.

Autor:	Fan S; Department of Psychology, Yale University, New Haven, CT 06520, USA.; The Rockefeller University, New York, NY 10065, USA., Dal Monte O; Department of Psychology, Yale University, New Haven, CT 06520, USA.; Department of Psychology, University of Turin, 10124 Torino, Italy., Nair AR; Department of Psychology, Yale University, New Haven, CT 06520, USA., Fagan NA; Department of Psychology, Yale University, New Haven, CT 06520, USA., Chang SWC; Department of Psychology, Yale University, New Haven, CT 06520, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.; Wu Tsai Institute, Yale University, New Haven, CT 06510, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 18. Date of Electronic Publication: 2023 Dec 18.
DOI:	10.1101/2023.12.18.572176
Abstrakt:	The prefrontal cortex is extensively involved in social exchange. During dyadic gaze interaction, multiple prefrontal areas exhibit neuronal encoding of social gaze events and context-specific mutual eye contact, supported by a widespread neural mechanism of social gaze monitoring. To explore causal manipulation of real-life gaze interaction, we applied weak closed-loop microstimulations that were precisely triggered by specific social gaze events to three prefrontal areas in monkeys. Microstimulations of orbitofrontal cortex (OFC), but not dorsomedial prefrontal or anterior cingulate cortex, enhanced momentary dynamic social attention in the spatial dimension by decreasing distance of one's gaze fixations relative to partner monkey's eyes. In the temporal dimension, microstimulations of OFC reduced the inter-looking interval for attending to another agent and the latency to reciprocate other's directed gaze. These findings demonstrate that primate OFC serves as a functionally accessible node in controlling dynamic social attention and suggest its potential for a therapeutic brain interface. Competing Interests: Declaration of Interests The authors declare no competing interests.
Databáze:	MEDLINE
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