| Autor: |
Porter HL; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center.; Oklahoma Nathan Shock Center., Ansere VA; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center., Undi RB; University of Oklahoma Health Sciences Center., Hoolehan W; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center., Giles CB; Oklahoma Medical Research Foundation., Brown CA; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center., Stanford D; Oklahoma Medical Research Foundation., Huycke MM; University of Oklahoma Health Sciences Center., Freeman WM; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center.; Oklahoma Nathan Shock Center., Wren JD; Oklahoma Medical Research Foundation.; University of Oklahoma Health Sciences Center.; Oklahoma Nathan Shock Center. |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 20. Date of Electronic Publication: 2023 Dec 20. |
| DOI: |
10.1101/2023.12.20.572465 |
| Abstrakt: |
DNA methylation data has been used to make "epigenetic clocks" which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methylation states. Here, we demonstrate how another hallmark of aging, genomic instability, influences methylation measurements in both bisulfite sequencing and methylation arrays. We found that non-methylation factors lead to "pseudomethylation" signals that are both confounding of epigenetic clocks and uniquely age predictive. Quantifying these covariates in aging studies will be critical to building better clocks and designing appropriate studies of epigenetic aging. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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