Relationship between steroid use and superinfections in SARS-CoV-2 patients. A systematic review and meta-analysis.

Autor: González Ramírez M; Medical Doctor; Specialist in critical medicine and intensive care. Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia., Hoyos Muñoz JA; Medical Doctor; Specialist in critical medicine and intensive care. Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia., Moreno Gómez GA; Medical Doctor; Clinical Epidemiologist. Ph.D. in Public Health. Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia., Aguirre Flórez M; Medical Doctor. Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia., Gómez González JF; Medical Doctor; Specialist in critical medicine and intensive care. Grupo de investigación en Medicina Crítica y Cuidado Intensivo (GIMCCI). Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia.
Jazyk: angličtina
Zdroj: Infection ecology & epidemiology [Infect Ecol Epidemiol] 2023 Nov 27; Vol. 13 (1), pp. 2277000. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
DOI: 10.1080/20008686.2023.2277000
Abstrakt: Introduction: The use of steroids has been proposed as a pharmacological approach to treat the SARS-CoV-2 infection to improve outcomes. However, there are doubts about safety against the development of superinfections and their worse outcomes. Objective: To establish the relative frequency of superinfection associated with using steroids in patients with SARS-CoV-2 infection. Materials and methods: We conducted a systematic literature review and meta-analysis using PRISMA standards in 5 databases (PubMed/Scopus/Cochrane/EMBASE/Google Scholar). The search was carried out between February 2020 and May 2023. The search terms were 'steroids' or 'superinfection' 'and' followed by 'SARS-CoV-2' or 'COVID-19'. Results: We found 77 studies, but only 10 with 3539 patients were included in the systematic review. All patients developed severe disease. The documented OR for superinfection through the meta-analysis was 1.437 (95% IC 0.869-2.378) with a p-value of 0.158 without showing a risk attributed to steroids and the development of superinfections. In the Funnel-plot analysis, no publication biases were found. Conclusion: No relationship was found between using steroids and superinfection in patients with SARS-CoV-2.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze: MEDLINE
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