A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study.

Autor: Wang R; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China., Wu S; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China., Wang J; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China., Li W; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China., Cui J; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China., Yao Z; Department of Cardiology, Tianjin Union Medical Center, Tianjin, China.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2024 Dec; Vol. 46 (1), pp. 2296002. Date of Electronic Publication: 2024 Jan 08.
DOI: 10.1080/0886022X.2023.2296002
Abstrakt: Objective: To explore the relationship between the serum uric acid to creatinine (UA/Cr) ratio and the prevalence of hypertension.
Methods: In this cross-sectional study, we included 8571 individuals from the China Health and Nutrition Survey. Logistic regression analysis and restricted cubic spline (RCS) were used to analyze the relationship between the UA/Cr ratio and hypertension.
Results: Compared with individuals without hypertension, individuals with hypertension had higher UA/Cr ratios. Multivariate logistic regression analysis showed that a higher UA/Cr ratio was closely related to a higher risk of hypertension (as a continuous variable, OR: 1.054, 95% CI: 1.014-1.095, p  = 0.007; as a categorical variable, Q3 vs. Q1, OR: 1.183, 95% CI: 1.011-1.384, p  = 0.035; Q4 vs. Q1, OR: 1.347, 95% CI: 1.146-1.582, p  < 0.001). Subgroup analysis revealed that the correlation between the UA/Cr ratio and hypertension risk was stable in all subgroups except for the subgroup with diabetes and the subgroup with a BMI ≥ 28 kg/m 2 ( p  < 0.05). Sensitivity analysis confirmed the robustness of the relationship between a higher UA/Cr ratio and a higher risk of hypertension ( p  < 0.05). The RCS showed that the UA/Cr ratio was nonlinearly related to hypertension risk. Further threshold effect showed that only a UA/Cr ratio less than 5.0 was related to hypertension risk (OR: 1.178, 95% CI: 1.086-1.278, p  < 0.001), and the 2-piecewise linear regression model was superior to the 1-line linear regression model ( p  < 0.05).
Conclusion: The UA/Cr ratio was associated with the prevalence of hypertension.
Databáze: MEDLINE
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