Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry.

Autor: Lacan C; Clinical Hematology Unit, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83 Bd de l'Hôpital, 75013, Paris, France., Lambert J; Institut national de la santé et de la recherche médicale (INSERM), U1153 CRESS, Paris, France.; Service de Biostatistique et Information Médicale, Hôpital Saint Louis, APHP, Paris, France., Forcade E; Clinical Hematology Unit, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Robin M; Clinical Hematology Unit, Hôpital Saint Louis, APHP, Paris, France., Chevallier P; Clinical Hematology Unit, Centre Hospitalier Universitaire de Nantes, Nantes, France., Loron S; Clinical Hematology Unit, Hôpital Lyon Sud, HCL, Lyon, France., Bulabois CÉ; Clinical Hematology Unit, Centre Hospitalier Universitaire de Grenoble, Grenoble, France., Orvain C; Clinical Hematology Unit, Centre Hospitalier Universitaire d'Angers, Angers, France., Ceballos P; Clinical Hematology Unit, Centre Hospitalier Universitaire de Montpellier, Montpellier, France., Daguindau E; Clinical Hematology Unit, Centre Hospitalier Universitaire de Besançon, Besançon, France., Charbonnier A; Clinical Hematology Unit, Centre Hospitalier Universitaire d'Amiens, Amiens, France., Chalandon Y; Clinical Hematology Unit, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Bernard M; Clinical Hematology Unit, Centre Hospitalier Universitaire de Rennes, Rennes, France., Simand C; Clinical Hematology Unit, Institut de Cancérologie Strasbourg Europe, Strasbourg, France., Rubio MT; Clinical Hematology Unit, Centre Hospitalier Universitaire de Nancy, Nancy, France., Turlure P; Clinical Hematology Unit, Centre Hospitalier Universitaire Dupuytren, Limoges, France., Maertens J; Department of Hematology, UZ Leuven, Leuven, Belgium., Huynh A; Clinical Hematology Unit, Oncopôle, Toulouse, France., Loschi M; Clinical Hematology Unit, Centre Hospitalier Universitaire de Nice, Nice, France., Bay JO; Clinical Hematology Unit, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Guillerm G; Clinical Hematology Unit, Centre Hospitalier Universitaire de Brest, Brest, France., Alani M; Clinical Hematology Unit, Centre Henri Becquerel, Rouen, France., Castilla-Llorente C; Clinical Hematology Unit, Institut Gustave Roussy, Villejuif, France., Poiré X; Clinical Hematology Unit, Clinique Universitaire Saint Luc, Leuven, Belgium., Chantepie S; Clinical Hematology Unit, Centre Hospitalier Universitaire de Caen, Caen, France., Maillard N; Clinical Hematology Unit, Centre Hospitalier Universitaire de Poitiers, Poitiers, France., Beguin Y; Clinical Hematology Unit, Centre Hospitalier Universitaire de Liège and University of Liège, Liège, Belgium., Marçais A; Clinical Hematology Unit, Hôpital Necker-Enfants Malades, APHP, Paris, France., Cornillon J; Clinical Hematology Unit, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France., Malfuson JV; Clinical Hematology Unit, Hôpitaux d'Instruction des Armées Percy, Clamart, France., Maury S; Clinical Hematology Unit, Hôpital Henri Mondor, APHP, Créteil, France., Meuleman N; Clinical Hematology Unit, Institut Jules Bordet, Brussels, Belgium., Villate A; Clinical Hematology Unit, Hôpital Bretonneau, Tours, France., Bekadja MA; Clinical Hematology Unit, Clinic of Hematology and Cell Therapy, EHU 1St November, Oran, Algeria., Walter-Petrich A; Institut national de la santé et de la recherche médicale (INSERM), U1153 CRESS, Paris, France.; Service de Biostatistique et Information Médicale, Hôpital Saint Louis, APHP, Paris, France., Jacque N; Clinical Hematology Unit, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83 Bd de l'Hôpital, 75013, Paris, France., Srour M; Clinical Hematology Unit, Centre Hospitalier Universitaire de Lille, Lille, France., Devillier R; Clinical Hematology Unit, Institut Paoli Calmette, Marseille, France., Nguyen S; Clinical Hematology Unit, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83 Bd de l'Hôpital, 75013, Paris, France. stephanie.nguyen-quoc@aphp.fr.
Jazyk: angličtina
Zdroj: Journal of hematology & oncology [J Hematol Oncol] 2024 Jan 07; Vol. 17 (1), pp. 2. Date of Electronic Publication: 2024 Jan 07.
DOI: 10.1186/s13045-023-01515-4
Abstrakt: The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis remains controversial. Moreover, the value of adding anti-thymoglobulin (ATG) to PTCy is unknown. A total of 1344 adult patients received an unmanipulated haploidentical transplant at 37 centers from 2012 to 2019 for hematologic malignancy. We compared the outcomes of patients according to the type of graft, using a propensity score analysis. In total population, grade II-IV and III-IV acute GVHD (aGVHD) were lower with BM than with PB. Grade III-IV aGVHD was lower with BM than with PB + ATG. All outcomes were similar in PB and PB + ATG groups. Then, in total population, adding ATG does not benefit the procedure. In acute leukemia, myelodysplastic syndrome and myeloproliferative syndrome (AL-MDS-MPS) subgroup receiving non-myeloablative conditioning, risk of relapse was twice greater with BM than with PB (51 vs. 22%, respectively). Conversely, risk of aGVHD was greater with PB (38% for aGVHD II-IV; 16% for aGVHD III-IV) than with BM (28% for aGVHD II-IV; 8% for aGVHD III-IV). In this subgroup with intensified conditioning regimen, risk of relapse became similar with PB and BM but risk of aGVHD III-IV remained higher with PB than with BM graft (HR = 2.0; range [1.17-3.43], p = 0.012).
(© 2023. The Author(s).)
Databáze: MEDLINE
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