Preparation and evaluation of blend polymer films for wound dressing using vancomycin-loaded polycaprolactone and carboxymethyl cellulose via crosslinking methods: Effect of mechanical strength, antibacterial activity, and cytotoxicity.

Autor: Meedecha P; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand., Srisang N; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand., Eawsakul K; Department of Applied Thai Traditional Medicine, School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand., Ongtanasup T; Department of Applied Thai Traditional Medicine, School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand., Tambunlertchai S; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand., Sokjabok S; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand., Chungcharoen T; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand., Srisang S; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand. Electronic address: siriwan.sr@kmitl.ac.th., Limmun W; Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Mar; Vol. 151, pp. 106339. Date of Electronic Publication: 2023 Dec 25.
DOI: 10.1016/j.jmbbm.2023.106339
Abstrakt: Polycaprolactone (PCL) and carboxymethyl cellulose (CMC) are two materials with beneficial properties for wound healing applications. Here, the simple preparation of PCL/CMC polymer films via the crosslinking method was demonstrated for the first time. The polymer films represented the suitable properties of liquid absorption and tensile strength to be used as a wound dressing. The blend polymer films can also load the vancomycin, which prolongs the drug release for effectiveness against S. aureus. The trifluoroethanol showed less toxicity in comparison with other crosslinking agents. This process can also be applied further in other medical devices and wound healing applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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