Autor: |
Val-Bernal JF; Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain; fernando.val@unican.es., Mayorga MM, Bercebal C, Cagigal ML |
Jazyk: |
angličtina |
Zdroj: |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2023 Oct-Dec; Vol. 64 (4), pp. 457-466. |
DOI: |
10.47162/RJME.64.4.01 |
Abstrakt: |
This review article aimed to postulate the existence of a specific arterial injury having as its histological hallmark a collection of macrophages loaded with lipids in the intima of small-sized and medium-sized arteries causing narrowing or complete obstruction. The proposal is made that a series of previously described entities, such as ionizing radiation arteriopathy, acute atherosis (foam-cell decidual arteriopathy), transplant chronic arteriopathy of solid organ allografts, and intratumoral-associated foam-cell arteriopathy constitute different manifestations of the same basic morphological process identified as obliterative foam-cell arteriopathy (OFCA). OFCA is a local (single-organ) lesion in the aforementioned diverse processes with variable etiopathogenesis but converges in a single morphological marker. This arteriopathy is essentially an intimal disease. The processes in which the OFCA appears are known under a variety of names partly dependent on the location of the lesion. The basic unifying mechanism of the different entities is endothelial activation and dysfunction (local arterial endotheliopathy), preferably in small-sized or medium-sized arteries (100 to 500 μm in external diameter). |
Databáze: |
MEDLINE |
Externí odkaz: |
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