Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan.

Autor: Fancello G; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy.; Department of Otorhinolaryngology, Careggi University Hospital, 50134, Florence, Italy., Fancello V; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy. virginia.fancello@gmail.com.; Ear Nose and Throat and Audiology Unit, Department of Neurosciences, University Hospital of Ferrara, 44124, Ferrara, Italy. virginia.fancello@gmail.com.; ENT Department, Azienda Ospedaliero Universitaria - Sassari, 07100, Sassari, Italy. virginia.fancello@gmail.com., Ehsani D; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy.; Ear Nose and Throat and Audiology Unit, Department of Neurosciences, University Hospital of Ferrara, 44124, Ferrara, Italy., Porpiglia V; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy.; Audiology Unit, Department of Specialistic Surgical Sciences, IRCCS Cà Granda Foundation, Policlinic of Milan, Milan, Italy., Piras G; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy., Caruso A; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy., Sanna M; Department of Otology and Skull Base Surgery, Otologic Group, 29121, Piacenza, Italy.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2024 Jun; Vol. 281 (6), pp. 2779-2789. Date of Electronic Publication: 2024 Jan 06.
DOI: 10.1007/s00405-023-08413-y
Abstrakt: Introduction: Tympanojugular paragangliomas (TJ PGLs) are rare tumors characterized by bone infiltration and erosion and a close relationship with critical structures, such as cranial nerves and internal carotid artery. For these reasons, their management represents a tough challenge. Since the fifties, radio-therapy (RT) has been proposed as an alternative treatment aimed at avoiding tumor progression. However, the indolent nature of the tumor, characterized by slow growth, is a crucial factor that needs to be considered before offering radiation.
Methods: This study aims to examine tumor progression in RT patients through a systematic review of the literature and in TJ PGL patients who underwent solely wait and scan at our department.
Results: The rate of tumor progression in the RT group was 8.9%, while in the wait and scan cohort was 12.9%. This data suggests the innate slow growth of PGLs. However, it is not possible to draw certain conclusions because of the wide heterogeneity of the studies.
Conclusion: When complete surgical excision of TJ PGLs is not feasible, appropriate counseling and patient selection, including comprehensive tumor classification, should be performed before proposing RT to control tumor progression, since wait and scan may represent a reasonable option in selected cases.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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