Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.

Autor: Ravichandran S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Erra-Diaz F; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; University of Buenos Aires, School of Medicine, Buenos Aires, Argentina., Karakaslar OE; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Leiden University Medical Center (LUMC), Leiden, the Netherlands., Marches R; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Kenyon-Pesce L; UConn Center on Aging, University of Connecticut, Farmington, CT, USA., Rossi R; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Chaussabel D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Nehar-Belaid D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., LaFon DC; Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Pascual V; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Palucka K; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Paust S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Nahm MH; Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Kuchel GA; UConn Center on Aging, University of Connecticut, Farmington, CT, USA., Banchereau J; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Immunoledge LLC, Montclair, NJ, USA., Ucar D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. duygu.ucar@jax.org.; Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT, USA. duygu.ucar@jax.org.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA. duygu.ucar@jax.org.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Feb; Vol. 25 (2), pp. 316-329. Date of Electronic Publication: 2024 Jan 05.
DOI: 10.1038/s41590-023-01717-5
Abstrakt: Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain unknown. We vaccinated 39 older adults (>60 years) with PPSV23 or PCV13 and observed comparable antibody responses (day 28) and plasmablast transcriptional responses (day 10); however, the baseline predictors were distinct. Analyses of baseline flow cytometry and bulk and single-cell RNA-sequencing data revealed a baseline phenotype specifically associated with weaker PCV13 responses, which was characterized by increased expression of cytotoxicity-associated genes, increased frequencies of CD16 + natural killer cells and interleukin-17-producing helper T cells and a decreased frequency of type 1 helper T cells. Men displayed this phenotype more robustly and mounted weaker PCV13 responses than women. Baseline expression levels of a distinct gene set predicted PPSV23 responses. This pneumococcal precision vaccinology study in older adults uncovered distinct baseline predictors that might transform vaccination strategies and initiate novel interventions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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