Chemical Composition of Commercial Cannabis.

Autor:	Wishart DS; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.; Department of Computing Science, University of Alberta, Edmonton, Alberta T6G 2E8, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada., Hiebert-Giesbrecht M; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Inchehborouni G; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Cao X; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Guo AC; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., LeVatte MA; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Torres-Calzada C; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Gautam V; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Johnson M; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Liigand J; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Wang F; Department of Computing Science, University of Alberta, Edmonton, Alberta T6G 2E8, Canada., Zahraei S; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Bhumireddy S; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Wang Y; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Zheng J; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Mandal R; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada., Dyck JRB; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
Jazyk:	angličtina
Zdroj:	Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jun 26; Vol. 72 (25), pp. 14099-14113. Date of Electronic Publication: 2024 Jan 05.
DOI:	10.1021/acs.jafc.3c06616
Abstrakt:	Cannabis is widely used for medicinal and recreational purposes. As a result, there is increased interest in its chemical components and their physiological effects. However, current information on cannabis chemistry is often outdated or scattered across many books and journals. To address this issue, we used modern metabolomics techniques and modern bioinformatics techniques to compile a comprehensive list of >6000 chemical constituents in commercial cannabis. The metabolomics methods included a combination of high- and low-resolution liquid chromatography-mass spectrometry (MS), gas chromatography-MS, and inductively coupled plasma-MS. The bioinformatics methods included computer-aided text mining and computational genome-scale metabolic inference. This information, along with detailed compound descriptions, physicochemical data, known physiological effects, protein targets, and referential compound spectra, has been made available through a publicly accessible database called the Cannabis Compound Database (https://cannabisdatabase.ca). Such a centralized, open-access resource should prove to be quite useful for the cannabis community.
Databáze:	MEDLINE
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