Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis.

Autor: Mejía-Salgado G; Institute of Translational Medicine (IMT), Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.; Institute of Translational Medicine (IMT), Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia., Muñoz-Vargas PT; Postgraduate Master's Program in Epidemiology Universidad CES, Medellín, Colombia.; Post-gradual Master's Program in Epidemiology Universidad del Rosario, Bogotá Colombia., Cifuentes-González C; Institute of Translational Medicine (IMT), Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.; Postgraduate Master's Program in Epidemiology Universidad CES, Medellín, Colombia.; Post-gradual Master's Program in Epidemiology Universidad del Rosario, Bogotá Colombia., Flórez-Esparza G; Institute of Translational Medicine (IMT), Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia., Paquentín-Jiménez R; Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, Hospital 'Dr. Luis Sánchez Bulnes,' México City, México., Castro-Monreal MÁ; Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, Hospital 'Dr. Luis Sánchez Bulnes,' México City, México., Medina-Galindo N; Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, Hospital 'Dr. Luis Sánchez Bulnes,' México City, México., Hernández-Herrera GN; Postgraduate Master's Program in Epidemiology Universidad CES, Medellín, Colombia.; Post-gradual Master's Program in Epidemiology Universidad del Rosario, Bogotá Colombia., Concha-Del-Río LE; Inflammatory Eye Disease Clinic, Asociación Para Evitar la Ceguera en México, Hospital 'Dr. Luis Sánchez Bulnes,' México City, México., de-la-Torre A; Institute of Translational Medicine (IMT), Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.; Post-gradual Master's Program in Epidemiology Universidad del Rosario, Bogotá Colombia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jan 05; Vol. 19 (1), pp. e0296784. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0296784
Abstrakt: Purpose: To establish the effects of anterior chamber inflammation (ACI) on the corneal endothelium parameters and central corneal thickness (CCT).
Methods: We conducted a comprehensive literature review using medical databases (PubMed, EMBASE, VHL, and medRxiv) on March 8, 2023, for studies that included patients with ACI who had undergone specular microscopy or pachymetry. Case series with >10 patients, cross-sectional, case-control, and cohort studies were included. The risk of bias was assessed using CLARITY tools and validated scales such as those by Hassan Murad et al. and Hoy et al. A narrative synthesis and a quantitative standardized mean difference meta-analysis, I2 heterogeneity assessment, and publication bias tests were conducted. The study was registered in PROSPERO (CRD42023420148) and approved by the Universidad del Rosario ethical committee (DVO005 2277- CV1712).
Results: Thirty-four studies, encompassing 1,388 eyes with ACI, were included. Compared with healthy controls, overall, ACI eyes show significant mean differences in endothelial parameters (endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX)) (P < 0.05). In the subgroup analysis compared with healthy controls, both active and chronic-recurrent ACI demonstrated a reduced ECD. An increased CV was observed in active, inactive, and chronic-recurrent ACI. Lower HEX was evident in inactive, acute, and chronic-recurrent ACI, while both active and acute ACI exhibited high CCT.
Conclusion: ACI leads to significant alterations in endothelial parameters and CCT. The primary contributors to these changes are increased IOP, uveitis duration, and intraocular surgeries. Further studies are needed to explore the impact of ACI etiology on the endothelium, potential biases in IOP measurements during acute ACI episodes, and the potential necessity for monitoring the endothelial parameters and CCT in patients with chronic ACI.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Mejía-Salgado et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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