| Autor: |
Agarkov NM; South-Western State University, 94 str. 50 years of October, Kursk 305040, Russian Federation, e-mail: vitalaxen@mail.ru.; Belgorod State National Research University, 85 Pobedy str., Belgorod 308015, Russian Federation., Osipova OA; Belgorod State National Research University, 85 Pobedy str., Belgorod 308015, Russian Federation.; National Medical Research Center for Therapy and Preventive Medicine, 10 build. 3 Petroverigsky Lane, Moscow 101990, Russian Federation., Kopylov AE; S.N.Fedorov National medical research center «MNTK Eye Microsurgery», 1 Rasskazovskoe highway, Tambov 392000, Russian Federation., Korovin EN; Voronezh State Technical University, 84 str. 20th October, Voronezh 394006, Russian Federation., Titov AA; South-Western State University, 94 str. 50 years of October, Kursk 305040, Russian Federation, e-mail: vitalaxen@mail.ru., Shmarova DR; South-Western State University, 94 str. 50 years of October, Kursk 305040, Russian Federation, e-mail: vitalaxen@mail.ru., Alymova MV; South-Western State University, 94 str. 50 years of October, Kursk 305040, Russian Federation, e-mail: vitalaxen@mail.ru. |
| Abstrakt: |
Arterial hypertension is one of the most common life-threatening diseases, adequate control of which is largely achieved by antihypertensive drugs, including the use of telmisartan. The aim of the study was to evaluate the effect of telmisartan chronotherapy on the parameters of daily monitoring of blood pressure during the daytime and at night in elderly patients with hypertension. The study is based on a comprehensive examination of 150 patients aged 60-74 years suffering from hypertension, who are divided into 2 groups: the main (n=76) and control (n=74). Patients with hypertension in the main group received telmisartan at a dose of 80 mg/day in the evening (20.00-22.00 hours), and in the control group - in the morning at the same dose (80 mg/day). Before treatment, after 3 months and after 6 months, patients of both groups underwent daily monitoring of blood pressure with the «BPLab monitor Mn SDP-3». It was found that the evening intake of telmisartan at a dose of 80 mg/day has a more significant effect than the morning intake of the same dose of telmisartan on the indicators of daily monitoring of systolic blood pressure and diastolic blood pressure in the evening, the systolic blood pressure time index in the evening. Chronotherapy with telmisartan in elderly patients with hypertension more effectively normalizes the daily blood pressure profile with the transfer of «non-dipper» to «dipper», reduces the hypertensive load and contributes to the achievement of target blood pressure levels. |
