Nutritional interventional studies in patients with multiple sclerosis: a scoping review of the current clinical evidence.

Autor: Tryfonos C; Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400, Myrina, Greece., Chrysafi M; Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400, Myrina, Greece., Vadikolias K; Department of Neurology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Berberoglou L; Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Campus (Dragana) Building 5, 68100, Alexandroupolis, Greece., Vorvolakos T; Department of Psychiatry, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Dimoliani S; Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400, Myrina, Greece., Tsourouflis G; Second Department of Surgery, Propedeutic, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece., Kontogiorgis C; Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Campus (Dragana) Building 5, 68100, Alexandroupolis, Greece., Antasouras G; Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400, Myrina, Greece., Giaginis C; Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400, Myrina, Greece. cgiaginis@aegean.gr.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Apr; Vol. 271 (4), pp. 1536-1570. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1007/s00415-023-12140-z
Abstrakt: A good nutritional status appears to slow down disease progression and ameliorate symptoms' intensity in patients with multiple sclerosis (MS). Up to date, there are several interventional studies, which have explored the potential beneficial effects of specific dietary patterns as well as specific bioactive nutrients against disease progression and symptomatology of MS patients. This is a thorough, scoping review, which aims to critically summarize and scrutinize the currently available clinical evidence of the potential beneficial effects of nutritional interventional studies against MS progression and symptomatology. This review was conducted to systematically map the research done in this area, as well as to identify gaps in knowledge. For this purpose, we thoroughly explored the most accurate scientific web databases, e.g., PubMed, Scopus, Web of Science, and Google Scholar to achieve the most relevant clinical human studies applying effective and characteristic keywords. There are currently several dietary patterns and specific bioactive nutrients that show promising results by slowing down disease progression and by improving MS symptoms. However, there are also certain conflicting results, while most of the existing studies enrolled a small number of MS patients. Nutritional interventions may exert substantial protective effects against MS progression and symptomatology. However, large, long-term, randomized, double-blind, controlled clinical trials with a prospective design are strongly recommended to delineate whether such nutritional intervention may attenuate disease progression, and improve symptomatology in MS patients.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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