Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice.

Autor: du Halgouet A; Institut National de la Santé et de la Recherche Médicale U932, PSL University, Institut Curie, Paris, France.; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Bruder K; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Peltokangas N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Darbois A; Institut National de la Santé et de la Recherche Médicale U932, PSL University, Institut Curie, Paris, France., Obwegs D; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Salou M; Institut National de la Santé et de la Recherche Médicale U932, PSL University, Institut Curie, Paris, France., Thimme R; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Hofmann M; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lantz O; Institut National de la Santé et de la Recherche Médicale U932, PSL University, Institut Curie, Paris, France.; Laboratoire d'Immunologie Clinique, Institut Curie, Paris, France.; Centre d'Investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428) Institut Curie, Paris, France., Sagar; Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. sagar@uniklinik-freiburg.de.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Feb; Vol. 25 (2), pp. 343-356. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1038/s41590-023-01710-y
Abstrakt: γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets. Epidermal and intestinal intraepithelial γδ T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments, we uncovered cellular states associated with cytotoxicity, innate-like rapid interferon-γ production and tissue repair functions displaying tissue residency hallmarks. Notably, our observations add nuance to the link between interleukin-17-producing γδ T cells and tissue residency. Moreover, transcriptional programs associated with tissue-resident γδ T cells are analogous to those of CD8 + tissue-resident memory T cells. Altogether, this study provides a multimodal landscape of tissue-adapted γδ T cells, revealing heterogeneity, lineage relationships and their tissue residency program.
(© 2024. The Author(s).)
Databáze: MEDLINE
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