Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents.

Autor: Boraey NF; Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt., Bebars MA; Department of Pediatrics, Princess Alexandra hospital, Harlow, UK., Wahba AA; Department of Pediatrics at SSMC (Sheikh Shakhbout Medical City, Abu Dhabi, UAE., Abd El Lateef HM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Attia MA; Department of Pediatrics at SKMC (Sheikh khalifa Medical City, Abu Dhabi, UAE., Elsayed AH; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt., Rashed KA; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt., Sorour EI; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt., Ahmed MF; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt., Abd-Elrehim GAB; Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt., Soliman AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehab MMM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Elhindawy EM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ibraheem AAA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehata H; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Yousif YM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hashem MIA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ahmed AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Emam AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. ahmedemam1111@yahoo.com., Gameil DM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelhady EM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelkhalek K; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Morsi WEMA; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Selim DM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Razek SA; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Ashraf B; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Saleh ASE; Department of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt., Eltrawy HH; Department of Chest diseases, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt., Alanwar MI; Department of Cardiothoracic surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Fouad RA; Department of Medical Biochemistry, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Omar WE; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Nabil RM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelhamed MR; Department of Clinical pathology, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt., Ibrahim MY; Department of Clinical pathology, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt., Malek MM; Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Afify MR; Department of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia., Alharbi MT; Department of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia., Nagshabandi MK; Department of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia., Tarabulsi MK; Department of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia., Qashqary ME; Department of Family and community medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia., Almoraie LM; Department of Family and community medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia., Salem HF; Department of Anesthesia, Faculty of Medicine, Benha University, Banha, Egypt., Rashad MM; Department of Anesthesia, Faculty of Medicine, Zagazig University, Zagazig, Egypt., El-Gaaly SAA; Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Ain-Shams, Egypt., El-Deeb NA; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdallah AM; Department of Family Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Fakhreldin AR; Department of Pediatrics, Faculty of Medicine, Aswan University, Aswan, Egypt., Hassouba M; Department of Pediatrics, SUNY Downstate Health Science University, Kings County Hospital, Brooklyn, NY, USA., Massoud YM; Department of Tropical Medicine, Faculty of Medicine, Ain-Shams University, Ain-Shams, Egypt., Attaya MSM; Department of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt., Haridi MK; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 Oct; Vol. 96 (5), pp. 1347-1354. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1038/s41390-023-02982-8
Abstrakt: Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.
Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.
Results: The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46-3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49-2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6-9.7]; P < 0.001.
Conclusions: The ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents.
Impact: Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19. To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents. The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19. The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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