Utilizing Artificial Intelligence-Based Deformable Registration for Global and Layer-Specific Cardiac MRI Strain Analysis in Healthy Children and Young Adults.

Autor:	Priya S; Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.). Electronic address: sarv-priya@uiowa.edu., Hartigan T; Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)., Perry SS; Department of Biostatistics, University of Iowa, Iowa City, Iowa (S.S.P.)., Goetz S; Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)., Dalla Pria OAF; Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)., Walling A; Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (S.P., T.H., S.G., O.A.F.D.P., A.W.)., Nagpal P; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (P.N.)., Ashwath R; Division of Pediatric Cardiology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa (R.A.)., Bi X; MR R&D, Siemens Medical Solutions USA, Inc., Los Angeles, California (X.B.)., Chitiboi T; Siemens Healthcare GmbH, Hamburg, Germany (T.C.).
Jazyk:	angličtina
Zdroj:	Academic radiology [Acad Radiol] 2024 Apr; Vol. 31 (4), pp. 1643-1654. Date of Electronic Publication: 2024 Jan 04.
DOI:	10.1016/j.acra.2023.12.029
Abstrakt:	Rationale and Objectives: The absence of published reference values for multilayer-specific strain measurement using cardiac magnetic resonance (CMR) in young healthy individuals limits its use. This study aimed to establish normal global and layer-specific strain values in healthy children and young adults using a deformable registration algorithm (DRA). Materials and Methods: A retrospective study included 131 healthy children and young adults (62 males and 69 females) with a mean age of 16.6 ± 3.9 years. CMR examinations were conducted using 1.5T scanners, and strain analysis was performed using TrufiStrain research prototype software (Siemens Healthineers, Erlangen, Germany). Global and layer-specific strain parameters were extracted from balanced Steady-state free precession cine images. Statistical analyses were conducted to evaluate the impact of demographic variables on strain measurements. Results: The peak global longitudinal strain (LS) was -16.0 ± 3.0%, peak global radial strain (RS) was 29.9 ± 6.3%, and peak global circumferential strain (CS) was -17.0 ± 1.8%. Global LS differed significantly between males and females. Transmural strain analysis showed a consistent pattern of decreasing LS and CS from endocardium to epicardium, while radial strain increased. Basal-to-apical strain distribution exhibited decreasing LS and increasing CS in both global and layer-specific analysis. Conclusion: This study uses DRA to provide reference values for global and layer-specific strain in healthy children and young adults. The study highlights the impact of sex and age on LS and body mass index on RS. These insights are vital for future cardiac assessments in children, particularly for early detection of heart diseases. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Xiaoming Bi reports a relationship with Siemens Medical Solutions USA, Inc., Los Angeles, CA, USA that includes: employment. Teodora Chitiboi reports a relationship with Siemens Healthcare GmbH, Hamburg, Germany that includes: employment. TC and XB are Siemens employees. However, they were not involved in the data acquisition and statistical analysis of the results obtained with the software prototype. Other authors declare no conflict of interest. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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