Mechanobiology of myeloid cells.

Autor: Janssen E; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, the Netherlands., van den Dries K; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, the Netherlands., Ventre M; Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125, Naples, Italy; Center for Advanced Biomaterials for Healthcare@CRIB, Fondazione Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, Naples, Italy; Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Italy., Cambi A; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, the Netherlands. Electronic address: alessandra.cambi@radboudumc.nl.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2024 Feb; Vol. 86, pp. 102311. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1016/j.ceb.2023.102311
Abstrakt: Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in the context of altered matrix mechanics in immune-related pathologies or in the response to implanted biomaterials. A detailed understanding of myeloid cell mechanosensing may eventually lead to more effective cell-based immunotherapies for cancer, the development of mechanically inspired therapies to target fibrosis, and the engineering of safer implants. This review covers these recent advances in the emerging field of mechanoimmunology of myeloid cells.
Competing Interests: Declaration of competing interest The authors declare they do not have any known competing financial interests or personal relationships that could have influenced the work reported in this manuscript.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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