Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Autor:	Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Gervais A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Taniguchi M; Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Saare L; Dept. of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Särekannu K; Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Le Voyer T; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Philippot Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Rosain J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Bizien L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Asano T; Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Garcia-Prat M; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain., Parra-Martínez A; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain., Migaud M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France., Tsumura M; Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Conti F; Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.; Dept. of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Belot A; National Reference Center for Rheumatic, and Autoimmune and Systemic Diseases in Children , Lyon, France.; Immunopathology Federation LIFE, Hospices Civils de Lyon , Lyon, France.; Hospices Civils de Lyon , Lyon, France.; International Center of Research in Infectiology, Lyon University, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL , Lyon, France., Rivière JG; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain., Morio T; Dept. of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Tanaka J; Dept. of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Javouhey E; Pediatric Intensive Care Unit, Hospices Civils de Lyon, Hopital Femme Mère Enfant , Lyon, France., Haerynck F; Dept. of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium., Duvlis S; Faculty of Medical Sciences, University 'Goce Delchev' , Stip, Republic of Northern Macedonia.; Institute of Public Health of the Republic of North Macedonia , Skopje, North Macedonia., Ozcelik T; Dept. of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey., Keles S; Meram Medical Faculty, Necmettin Erbakan University , Konya, Turkey., Tandjaoui-Lambiotte Y; Pulmonology and Infectious Disease Department, Saint Denis Hospital, Saint Denis, France.; INSERM UMR 1137 IAME, Paris, France.; INSERM UMR 1272 Hypoxia and Lung, Bobigny, France., Escoda S; Pediatric Dept., Saint-Denis Hospital, Saint-Denis, France., Husain M; Pediatric Dept., Saint-Denis Hospital, Saint-Denis, France., Pan-Hammarström Q; Division of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Hammarström L; Division of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Ahlijah G; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France., Abi Haidar A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France., Soudee C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France., Arseguel V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France., Abolhassani H; Division of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences , Tehran, Iran., Sahanic S; Dept. of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Tancevski I; Dept. of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Nukui Y; Dept. of Infection Control and Prevention, Medical Hospital, TMDU, Tokyo, Japan., Hayakawa S; Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Chrousos GP; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece., Michos A; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.; First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Greece., Tatsi EB; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.; First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Greece., Filippatos F; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.; First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Greece., Rodriguez-Palmero A; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona, Spain.; Dept. of Pediatrics, Germans Trias i Pujol University Hospital, UAB , Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) , Madrid, Spain., Troya J; Dept. of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain., Tipu I; University of Management and Technology , Lahore, Pakistan., Meyts I; Dept. of Immunology, Laboratory of Inborn Errors of Immunity, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.; Dept. of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, Leuven, Belgium., Roussel L; Dept. of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada.; Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre , Montréal, Canada., Ostrowski SR; Dept. of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Schidlowski L; Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe , Curitiba, Brazil., Prando C; Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe , Curitiba, Brazil., Condino-Neto A; Dept. of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Cheikh N; Pediatric Hematology Unit, University Hospital of Besançon , Besançon, France., Bousfiha AA; Dept. of Pediatric Infectious Disease and Clinical Immunology, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco., El Bakkouri J; Laboratory of Immunology, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University , Casablanca, Morocco., Peterson P; Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Pujol A; Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies , Barcelona, Spain., Lévy R; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Quartier P; University Paris Cité, Imagine Institute , Paris, France.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Vinh DC; Dept. of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada.; Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre , Montréal, Canada., Boisson B; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Borghesi A; Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo , Pavia, Italy., Pession A; Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy., Andreakos E; Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens , Athens, Greece., Marr N; Research Branch, Sidra Medicine , Doha, Qatar., Mentis AA; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece., Mogensen TH; Dept. of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Dept. of Biomedicine, Aarhus University, Aarhus, Denmark., Rodríguez-Gallego C; Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System , Las Palmas, Spain.; Dept. of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.; Dept. of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain., Soler-Palacin P; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain., Colobran R; Immunology Division, Genetics Dept., Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Spain., Tillmann V; Dept. of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Neven B; University Paris Cité, Imagine Institute , Paris, France.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Trouillet-Assant S; Hospices Civils de Lyon , Lyon, France.; International Center of Research in Infectiology, Lyon University, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL , Lyon, France.; Joint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital , Pierre-Bénite, France.; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL , Lyon, France., Brodin P; Unit for Clinical Pediatrics, Dept. of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.; Department of Immunology and Inflammation, Imperial College London, London, UK., Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Zhang Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Martinón-Torres F; Translational Pediatrics and Infectious Diseases, Pediatrics Dept., Hospital Clínico Universitario de Santiago, Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain.; GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidad de Santiago de Compostela , Galicia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III , Madrid, Spain., Salas A; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III , Madrid, Spain.; Facultade de Medicina, Unidade de Xenética, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, and GenPoB Research Group, IDIS, SERGAS , Galicia, Spain., Gómez-Carballa A; GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidad de Santiago de Compostela , Galicia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III , Madrid, Spain.; Facultade de Medicina, Unidade de Xenética, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, and GenPoB Research Group, IDIS, SERGAS , Galicia, Spain., Gonzalez-Granado LI; Immunodeficiencies Unit, Hospital 12 de octubre, Research Institute Hospital 12 octubre , Madrid, Spain., Kisand K; Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Okada S; Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.; University Paris Cité, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA.; Howard Hughes Medical Institute , New York, NY, USA.; Dept. of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2024 Feb 05; Vol. 221 (2). Date of Electronic Publication: 2024 Jan 04.
DOI:	10.1084/jem.20231353
Abstrakt:	We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. (© 2024 Bastard et al.)
Databáze:	MEDLINE
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