Twenty years in the making: tolerance in a living-related kidney transplant recipient.

Autor: Alotaibi M; Comprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Meotaibi@hotmail.com.; Umm Al-Qura University, College of Medicine, Makkah, Saudi Arabia. Meotaibi@hotmail.com., Alahmadi Z; Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA., Desai N; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA., Brennan DC; Comprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Kant S; Comprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Journal of nephrology [J Nephrol] 2024 Jul; Vol. 37 (6), pp. 1711-1713. Date of Electronic Publication: 2024 Jan 04.
DOI: 10.1007/s40620-023-01843-1
Abstrakt: Kidney transplant recipients require lifelong immunosuppression to prevent graft rejection. However, immunosuppression is associated with adverse effects. A minority of kidney transplant recipients can be weaned off immunosuppression and maintain their graft function, a situation referred to as "functional or operational tolerance". We describe a case of a 70-year-old man who received a haploidentical hematopoietic cell transplant for lymphoma 22 years before receiving a kidney transplant from the same donor and was weaned off all immunosuppression by four months post-transplant. Tolerance was present, and there has been no graft rejection or graft vs. host disease. This case demonstrates successful long-term hematopoietic chimerism and functional tolerance after receiving a kidney transplant from the same donor.
(© 2024. The Author(s) under exclusive licence to Italian Society of Nephrology.)
Databáze: MEDLINE
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