Oral follicular lymphoma: a clinicopathologic and molecular study.

Autor: Souza LL; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Cáceres CVBL; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Sant'Ana MSP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Penafort PVM; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Andrade BAB; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pontes HAR; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Castro WH; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Xavier-Júnior JCC; Pathology Institute of Araçatuba and School of Medicine, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba, Brazil., Santos-Silva AR; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Lopes MA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Soares CD; Getúlio Sales Diagnósticos, Natal, Brasil., Robinson L; Department of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., van Heerden WFP; Department of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Burbano RMR; Laboratory of Molecular Biology, Ophir Loyola Hospital, Belém, Brazil., Assis-Mendonça GR; Multipat Anatomic Pathology and Molecular Pathology Laboratory, Campinas, Brazil.; Collaborating Researcher Program, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil., Vassallo J; Multipat Anatomic Pathology and Molecular Pathology Laboratory, Campinas, Brazil., Sousa SF; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Vargas PA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. felipepfonseca@hotmail.com.
Jazyk: angličtina
Zdroj: Journal of hematopathology [J Hematop] 2023 Dec; Vol. 16 (4), pp. 199-208. Date of Electronic Publication: 2023 Nov 02.
DOI: 10.1007/s12308-023-00563-6
Abstrakt: Follicular lymphoma is a hematolymphoid neoplasm that originates from germinal center B cells. It is made up of a combination of small cleaved centrocytes and a varying quantity of larger non-cleaved centroblasts to describe the clinical, microscopic, immunohistochemical, and molecular features of oral follicular lymphomas. Follicular lymphomas affecting the oral cavity were retrieved from pathology files. Immunohistochemistry was performed to confirm the diagnosis, and fluorescence in situ hybridization (FISH) was employed to detect rearrangements in BCL2, BCL6, and MYC genes. Clinical and follow-up data were obtained from the patient's medical and pathology files. Twenty cases were obtained. There was an equal sex distribution (10 males: 10 females) and a mean age of 60.9 years (range: 10-83 years-old). Lesions presented as asymptomatic swellings, usually in the palate (10 cases) and the buccal mucosa (7 cases). Five patients presented with concomitant nodal involvement. Microscopic evaluation depicted the follicular growth pattern with diffuse areas in six cases. Grades 1 and 2 follicular lymphomas represented 12 cases, while grade 3A neoplasms accounted for other 8 cases. Two cases showed rearrangements in MYC, BCL2, and BCL6 genes, while single BCL2 translocation was found in eight cases. Two cases had no translocation. Three patients deceased and the 2-year overall survival achieved 88%. Follicular lymphoma affecting the oral cavity is uncommon, usually affects the palate as a non-ulcerated swelling and the presence of a systemic disease most always be ruled out.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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