Medical help-seeking intentions among patients with early Alzheimer's disease.

Autor:	Villarejo-Galende A; Department of Neurology, Hospital Universitario 12 de Octubre, Instituto de Investigación Imas12, Universidad Complutense de Madrid, Madrid, Spain., García-Arcelay E; Medical Department, Roche Farma, Madrid, Spain., Piñol-Ripoll G; Cognitive Disorders Unit, Hospital Universitari Santa Maria de Lleida, Lleida, Spain., Del Olmo-Rodríguez A; Department of Neurology, Hospital Universitario Dr. Peset, Valencia, Spain., Viñuela F; Cognitive Impairment Unit, Hospital Universitario Virgen Macarena, Seville, Spain., Boada M; Ace Alzheimer Center Barcelona, Barcelona, Spain., Franco-Macías E; Dementia Unit, Department of Neurology, Hospital Universitario Virgen del Rocío, Seville, Spain., Ibañez de la Peña A; Policlínica Guipúzcoa, San Sebastián, Spain., Riverol M; Department of Neurology, Clínica Universidad de Navarra, University of Navarre, Pamplona, Spain., Puig-Pijoan A; Cognitive Impairment and Movement Disorders Unit, Department of Neurology, Hospital del Mar, Barcelona, Spain., Abizanda-Soler P; Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain., Arroyo R; Department of Neurology, Hospital Universitario Quirónsalud, Madrid, Spain., Baquero-Toledo M; Grup d'Investigació en Malaltia d'Alzheimer, Department of Neurology, Hospital Universitari i Politècnic La Fe, Valencia, Spain., Feria-Vilar I; Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain., Balasa M; Unit of Alzheimer's Disease and Other Cognitive Disorders, Hospital Clínic, Barcelona, Spain., Berbel Á; Department of Neurology, Hospital Central de la Cruz Roja, Madrid, Spain., Rodríguez-Rodríguez E; Department of Neurology, Hospital Universitario de Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain., Vieira-Campos A; Department of Neurology, Hospital Universitario de La Princesa, Madrid, Spain., Garcia-Ribas G; Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain., Rodrigo-Herrero S; Memory Unit, Department of Neurology, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain., Lleó A; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Maurino J; Medical Department, Roche Farma, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2023 Dec 19; Vol. 14, pp. 1290002. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
DOI:	10.3389/fpsyt.2023.1290002
Abstrakt:	Background: Limited information is available on the active process of seeking medical help in patients with Alzheimer's disease (AD) at early stages. The aim of this study was to assess the phenomenon of medical help-seeking in early AD and to identify associated factors. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD (National Institute on Aging/Alzheimer's Association criteria), a Mini-Mental State Examination (MMSE) score ≥ 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5-1.0. A multivariate logistic regression analysis was conducted. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years, 50.3% were female, and 87.2% had a CDR-GS score of 0.5. Mean disease duration was 1.4 (1.8) years. Ninety-four (63.1%) patients sought medical help, mostly from neurologists. Patients with help-seeking intentions were mostly female (60.6%) with a CDR-GS score of 0.5 (91.5%) and had a greater awareness of diagnosis, poorer quality of life, more depressive symptoms, and a more severe perception of their condition than their counterparts. Lack of help-seeking intentions was associated with male sex ( p  = 0.003), fewer years of education ( p  = 0.005), a low awareness of diagnosis ( p  = 0.005), and a low emotional consequence of the condition ( p  = 0.016). Conclusion: Understanding the phenomenon of active medical help-seeking may facilitate the design of specific strategies to improve the detection of cognitive impairment, especially in patients with a lower level of educational attainment and poor awareness of their condition. Competing Interests: EG-A and JM are employees of Roche Farma Spain. AV-G discloses honoraria from a consulting/advisory role with KRKA, Kern Pharma, Exeltis, Esteve, Roche, AbbVie, Schwabe, Neuraxpharm, Nutricia, and Alter. AO-R discloses honoraria from a consulting/advisory role with Alter, Biocross, Biogen, KRKA, Esteve, Schwabe, Nutricia, and Lilly. EF-M discloses honoraria from a consulting/advisory role with Kern Pharma, Esteve, Roche, and Neuraxpharm. MeB discloses honoraria from a consulting/advisory role with Grifols, Araclon Biotech, Roche, Lilly, Merck, Biogen, Zambon, Novo-Nordisk, Bioiberica, Biogen, Eisai, Servier, and Schwabe Pharma. RA discloses their participation on an advisory board and having received speaking fees from Almirall, Bayer, Biogen, Merck, Novartis, Roche, Sanofi, and Teva. AL discloses honoraria from a consulting/advisory role with Grifols, Fujirebio-Europe, Novartis, Roche, Otsuka, Nutricia, Zambón, Biogen, Lilly, and KRKA. A preliminary report of this data was presented as an eposter at the 9th Congress of the European Academy of Neurology (EPO-187, Budapest, Hungary; July 1–4, 2023). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Villarejo-Galende, García-Arcelay, Piñol-Ripoll, del Olmo-Rodríguez, Viñuela, Boada, Franco-Macías, Ibañez de la Peña, Riverol, Puig-Pijoan, Abizanda-Soler, Arroyo, Baquero-Toledo, Feria-Vilar, Balasa, Berbel, Rodríguez-Rodríguez, Vieira-Campos, Garcia-Ribas, Rodrigo-Herrero, Lleó and Maurino.)
Databáze:	MEDLINE
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