Association between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential cause.

Autor: Yu Y; Biomedical Research Institute, School of Medicine, Pusan National University, Yangsan, Korea., Lee B; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea., Shin K; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea.; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea., Kim K; Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital, Busan, Korea., Lee HJ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Department of Pathology, School of Medicine, Pusan National University, Yangsan, Korea., Shin JO; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea.; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea., Lee J; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea.; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea., Kim HS; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea., Kim BS; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea., Kim MB; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea., Kim YH; Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Korea.; Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea., Ko HC; Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea.; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Jazyk: angličtina
Zdroj: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2024 Sep; Vol. 38 (9), pp. 1776-1782. Date of Electronic Publication: 2024 Jan 03.
DOI: 10.1111/jdv.19746
Abstrakt: Background: Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months.
Objectives: Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation.
Methods: Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses.
Results: Some microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation.
Conclusions: The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.
(© 2024 European Academy of Dermatology and Venereology.)
Databáze: MEDLINE
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