Change in abdominal obesity after colon cancer surgery - effects of left-sided and right-sided colonic resection.

Autor: Kays Mohammed Ali Y; Department of Endocrinological Research, Copenhagen University Hospital -Amager and Hvidovre, Hvidovre, Denmark.; Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dolin TG; Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; CopenAge, Copenhagen Center for Clinical Age Research, University of Copenhagen, Copenhagen, Denmark., Damm Nybing J; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark., Lykke J; Department of Surgery, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Hvid Linden F; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark., Høgh-Schmidt E; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Christensen JF; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences at the University of Southern Denmark, Odense, Denmark.; Digestive Disease Center, Bispebjerg Hospital, Copenhagen, Denmark., Nielsen YJW; Department of Radiology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Stenfatt Larsen J; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Madsbad S; Department of Endocrinological Research, Copenhagen University Hospital -Amager and Hvidovre, Hvidovre, Denmark., Sidenius Johansen J; Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Svane MS; Department of Endocrinological Research, Copenhagen University Hospital -Amager and Hvidovre, Hvidovre, Denmark.; Department of Gastrointestinal Surgery, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark., Lang Lehrskov L; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. louise.lang.lehrskov.01@regionh.dk.; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark. louise.lang.lehrskov.01@regionh.dk.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Apr; Vol. 48 (4), pp. 533-541. Date of Electronic Publication: 2024 Jan 03.
DOI: 10.1038/s41366-023-01445-8
Abstrakt: Background: Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots.
Material and Methods: Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately.
Results: A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2-9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2-6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2-7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4-9%, p < 0.001) increase in SAT and a 4% (95% CI: 1-7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2-10%, p < 0.01) after 3 years.
Conclusion: After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT.
(© 2023. The Author(s).)
Databáze: MEDLINE
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