Unraveling the diversity and functions of tissue-resident plasma cells.

Autor: Tellier J; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. tellier@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tellier@wehi.edu.au., Tarasova I; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Nie J; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Smillie CS; Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA., Fedele PL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Haematology Department, Monash Health, Clayton, Victoria, Australia.; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Cao WHJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia., Groom JR; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Belz GT; The University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia., Bhattacharya D; Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA., Smyth GK; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia., Nutt SL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. nutt@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. nutt@wehi.edu.au.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Feb; Vol. 25 (2), pp. 330-342. Date of Electronic Publication: 2024 Jan 03.
DOI: 10.1038/s41590-023-01712-w
Abstrakt: Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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