Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice.

Autor: Hanrahan J; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Steeves KL; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Locke DP; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., O'Brien TM; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Maekawa AS; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Amiri R; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Macgowan CK; Translational Medicine, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada., Baschat AA; Department of Gynecology and Obstetrics, Johns Hopkins Center for Fetal Therapy, Johns Hopkins University, Baltimore, MD, 21287, USA., Kingdom JC; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, M5G 1E2, Canada.; Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Simpson AJ; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, M1C 1A4, Canada., Simpson MJ; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON, M1C 1A4, Canada., Sled JG; Translational Medicine, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, M5G 1E2, Canada.; Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, M5T 3H7, Canada., Jobst KJ; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada., Cahill LS; Department of Chemistry, Memorial University of Newfoundland, Arctic Avenue, St. John's, NL, A1C 5S7, Canada. lcahill@mun.ca.; Discipline of Radiology, Memorial University of Newfoundland, St. John's, NL, A1C 5S7, Canada. lcahill@mun.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jan 03; Vol. 14 (1), pp. 399. Date of Electronic Publication: 2024 Jan 03.
DOI: 10.1038/s41598-023-50781-2
Abstrakt: While microplastics have been recently detected in human blood and the placenta, their impact on human health is not well understood. Using a mouse model of environmental exposure during pregnancy, our group has previously reported that exposure to polystyrene micro- and nanoplastics throughout gestation results in fetal growth restriction. While polystyrene is environmentally relevant, polyethylene is the most widely produced plastic and amongst the most commonly detected microplastic in drinking water and human blood. In this study, we investigated the effect of maternal exposure to polyethylene micro- and nanoplastics on fetal growth and placental function. Healthy, pregnant CD-1 dams were divided into three groups: 10 6  ng/L of 740-4990 nm polyethylene with surfactant in drinking water (n = 12), surfactant alone in drinking water (n = 12) or regular filtered drinking water (n = 11). At embryonic day 17.5, high-frequency ultrasound was used to investigate the placental and fetal hemodynamic responses following exposure. While maternal exposure to polyethylene did not impact fetal growth, there was a significant effect on placental function with a 43% increase in umbilical artery blood flow in the polyethylene group compared to controls (p < 0.01). These results suggest polyethylene has the potential to cause adverse pregnancy outcomes through abnormal placental function.
(© 2024. The Author(s).)
Databáze: MEDLINE
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