Symptomatic Lymphocele After Robot-Assisted Pelvic Lymphadenectomy as Part of the Primary Surgical Treatment for Cervical and Endometrial Cancer: A Retrospective Cohort Study.

Autor:	de Jong A; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Baeten IGT; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Jansen A; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoogendam JP; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Jürgenliemk-Schulz IM; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology (Dr. Jürgenliemk-Schulz), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Zweemer RP; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Gerestein CG; Department of Gynecologic Oncology (Jong, Jansen, Drs. Baeten, Hoogendam, Jürgenliemk-Schulz, Zweemer, and Gerestein), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: C.G.Gerestein-2@umcutrecht.nl.
Jazyk:	angličtina
Zdroj:	Journal of minimally invasive gynecology [J Minim Invasive Gynecol] 2024 Mar; Vol. 31 (3), pp. 243-249.e2. Date of Electronic Publication: 2024 Jan 01.
DOI:	10.1016/j.jmig.2023.12.010
Abstrakt:	Study Objectives: Pelvic lymph node dissection (PLND) is part of the primary treatment for early-stage cervical cancer and high-intermediate risk or high-risk endometrial cancer. Pelvic lymphocele is a postoperative complication of PLND, and when symptomatic, lymphoceles necessitate treatment. The aim of this study was to investigate the incidence and risk factors of symptomatic lymphocele after robot-assisted laparoscopic PLND in cervical and endometrial cancer. Design: Retrospective cohort study. Setting: Single-center academic hospital. Patients: Two hundred and fifty-eight patients with cervical cancer and 129 patients with endometrial cancer. Interventions: Pelvic lymphadenectomy by robot-assisted laparoscopic surgery. Measurements and Main Results: The authors retrospectively included all patients with early-stage cervical cancer and high-intermediate risk or high-risk endometrial cancer who underwent pelvic lymphadenectomy by robot-assisted laparoscopic surgery between 2008 and 2022. Medical records were reviewed for the occurrence of a symptomatic lymphocele. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for developing a symptomatic lymphocele. In total, 387 patients, 258 with cervical cancer and 129 with endometrial cancer, were included in the study. The overall incidence of symptomatic lymphoceles was 9.6% with a median follow-up of 47 months [interquartile range 23-61]. For the entire cohort, smoking was the only significant risk factor for symptomatic lymphoceles identified in univariate (OR 2.47, 95% CI 1.19-5.11) and multivariate analysis (OR 2.42, 95% CI 1.16-5.07). For cervical cancer, body mass index (BMI) (OR 1.09, 95% CI 1.00-1.17) and prior abdominal surgery (OR 2.75, 95% CI 1.22-6.17) were also identified as significant independent risk factors. For endometrial cancer, age was identified as a significant independent risk factor (OR 0.90, 95% CI 0.83-0.97). Conclusion: This single-center cohort study demonstrated an incidence of almost 10% of symptomatic lymphoceles after robot-assisted laparoscopic PLND for cervical cancer and endometrial cancer, with a higher risk observed among patients who smoke at the time of diagnosis. Furthermore, risk factors differ between the 2 populations, necessitating further studies to establish risk models. (Copyright © 2024 AAGL. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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