CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy.

Autor:	Schoumacher C; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France., Derangère V; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.; INSERM LNC-UMR1231 Research Center, TIRECS Team, Dijon, France., Gaudillière-Le Dain G; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France., Huppe T; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France., Rageot D; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.; INSERM LNC-UMR1231 Research Center, TIRECS Team, Dijon, France., Ilie A; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France., Vienot A; Department of Medical Oncology, CHU Besançon, Besançon, France., Borg C; Department of Medical Oncology, CHU Besançon, Besançon, France., Monnien F; Department of Pathology, CHU Besançon, Besançon, France., Bibeau F; Department of Pathology, CHU Besançon, Besançon, France., Truntzer C; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.; INSERM LNC-UMR1231 Research Center, TIRECS Team, Dijon, France., Ghiringhelli F; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France.; INSERM LNC-UMR1231 Research Center, TIRECS Team, Dijon, France.; Genetic and Immunology Medical Institute, GIMI, Dijon, France.; Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France.
Jazyk:	angličtina
Zdroj:	Oncoimmunology [Oncoimmunology] 2023 Dec 21; Vol. 13 (1), pp. 2294563. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).
DOI:	10.1080/2162402X.2023.2294563
Abstrakt:	Stratification of the prognosis of pancreatic cancer (PDAC) patients treated by surgery is based solely on clinical variables, such as tumor stage and node status. The development of biomarkers of relapse is needed, especially to drive administration of adjuvant therapy in this at-risk population. Our study evaluates the prognostic performance of a CD3- and CD8-based immune score. CD3, CD8 and Foxp3 expression were evaluated on whole slides in two retrospective PDAC cohorts totaling 334 patients. For this study, we developed an immune score to estimate CD3 and CD8 infiltration in both tumor core and invasive margin using computer-guided analysis with QuPath software. Variables were combined in a dichotomous immune score. The association between immune and clinical scores, and both PFS and OS was investigated. We observed that a dichotomous immune score predicts both PFS and OS of localized PDAC. By univariate and multivariate analysis, immune score, tumor grade, adjuvant therapy, lymph node status, and adjuvant chemotherapy administration were associated with PFS and OS. We subsequently associated the PDAC immune score and clinical variables in a combined score. This combined score predicted patient outcomes independently of adjuvant or neoadjuvant treatment, and improved patient prognostic prediction compared to clinical variables or immune score alone. Competing Interests: No potential conflict of interest was reported by the author(s). (© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.)
Databáze:	MEDLINE
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