| Autor: |
Kilpatrick C, Hughes MJ, Light KE, Serbus DC |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1986 Nov 12; Vol. 131 (1), pp. 111-7. |
| DOI: |
10.1016/0014-2999(86)90523-6 |
| Abstrakt: |
Isolated, spontaneously beating atrial pairs from rabbits and guinea-pigs were used to determine and to compare the activity of ranitidine and tiotidine as antagonists of histamine stimulated chronotropic activity. Ranitidine produced a classical competitive, reversible antagonism of histamine effects with a pA2 in rabbit atria of 8.2. In contrast, tiotidine produced both a dextral shift of the log dose-response curve, as well as a previously unreported suppression in the maximal response produced by histamine. In accordance with receptor theory, this type of activity represents a dualistic antagonism of histamine chronotropic responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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