Correlation Between Pre-Operative Diffusion Tensor Imaging Indices and Post-Operative Outcome in Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis.

Autor:	Mohammadi M; School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Roohollahi F; Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Yas Spine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran., Mahmoudi MM; Department of General Surgery, Shahid Mofateh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohammadi A; School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Mohamadi M; School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Kankam SB; Image guided Neurosurgery Lab, Department of Neurosurgery, Brigham and Women Hospital, Harvard Medical School, Boston, MA, USA.; Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ghamari Khameneh A; Department of Radiology, Advanced Diagnostic and Interventional Radiology (ADIR) Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran., Baghdasaryan D; Nairi Medical Center, Yerevan, Armenia., Farahbakhsh F; Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran., Martin AR; Department of Neurosurgery, University of California Davis, Davis, CA, USA., Harrop J; Department of Neurological and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA., Rahimi-Movaghar V; Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Universal Scientific Education and Research Network (USERN), Tehran, Iran.; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Global spine journal [Global Spine J] 2024 Jul; Vol. 14 (6), pp. 1800-1817. Date of Electronic Publication: 2024 Jan 03.
DOI:	10.1177/21925682231225634
Abstrakt:	Study Design: Systematic review. Objectives: The correlation between pre-operative diffusion tensor imaging (DTI) metrics and post-operative clinical outcomes in patients with degenerative cervical myelopathy (DCM) has been widely investigated with different studies reporting varied findings. We conducted a systematic review to determine the association between DTI metric and clinical outcomes after surgery. Methods: We identified relevant articles that investigated the relationship between pre-operative DTI indices and post-operative outcome in DCM patients by searching PubMed/MEDLINE, Web of Science, Scopus, and EMBASE from inception until October 2023. In addition, quantitative synthesis and meta-analyses were performed. Results: FA was significantly correlated with postoperative JOA or mJOA across all age and follow up subgroups, changes observed in JOA or mJOA from preoperative to postoperative stages (Δ JOA or Δ mJOA) in subgroups aged 65 and above and in those with a follow-up period of 6 months or more, as well as recovery rate in all studies pooled together and also in the under-65 age bracket. Additionally, a significant correlation was demonstrated between recovery rate and ADC across all age groups. No other significant correlations were discovered between DTI parameters (MD, AD, and ADC) and post-operative outcomes. Conclusion: DTI is a quantitative noninvasive evaluation tool that correlates with severity of DCM. However, the current evidence is still elusive regarding whether DTI metric is a validated tool for predicting the degree of post-operative recovery, which could potentially be useful in patient selection for surgery. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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