A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients.

Autor:	Snyder WE; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Vértes PE; Department of Psychiatry, University of Cambridge, Cambridge, UK., Kyriakopoulou V; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK., Wagstyl K; Wellcome Centre for Human Neuroimaging, University College London, London, UK., Williams LZJ; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK., Moraczewski D; Data Science and Sharing Team, National Institute of Mental Health, Bethesda, Maryland, USA., Thomas AG; Data Science and Sharing Team, National Institute of Mental Health, Bethesda, Maryland, USA., Karolis VR; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, UK., Seidlitz J; Lifespan Brain Institute, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rivière D; Université Paris-Saclay, CEA, CNRS, Neurospin, Baobab, Gif-sur-Yvette, 91191, France., Robinson EC; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK., Mangin JF; Université Paris-Saclay, CEA, CNRS, Neurospin, Baobab, Gif-sur-Yvette, 91191, France., Raznahan A; Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA., Bullmore ET; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire & Peterborough NHS Foundation Trust, Cambridge, UK.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 20. Date of Electronic Publication: 2023 Dec 20.
DOI:	10.1101/2023.12.19.572454
Abstrakt:	We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from each magnetic resonance imaging (MRI) scan in an adult cohort (N=34,725; 45-82 years). Networks estimated from pairwise similarities of 40 sulci on 5 morphological metrics comprised two clusters of sulci, represented also by the bipolar distribution of sulci on a linear-to-complex dimension. Linear sulci were more heritable and typically located in unimodal cortex; complex sulci were less heritable and typically located in heteromodal cortex. Aligning these results with an independent fetal brain MRI cohort (N=228; 21-36 gestational weeks), we found that linear sulci formed earlier, and the earliest and latest-forming sulci had the least between-adult variation. Using high-resolution maps of cortical gene expression, we found that linear sulcation is mechanistically underpinned by trans-sulcal gene expression gradients enriched for developmental processes. Competing Interests: Declaration of interests E.T.B. has consulted for GlaxoSmithKline, SR One, Sosei Heptares, Boehringer Ingelheim and Monument Therapeutics. E.T.B. and J.S. are co-founders and stockholders of Centile Bio Inc. All other authors declare no conflicts of interest.
Databáze:	MEDLINE
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