Mapping causal links between prefrontal cortical regions and intra-individual behavioral variability.

Autor: Alizadeh Mansouri F; Cognitive Neuroscience Laboratory, Department of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. Farshad.mansouri@monash.edu.; RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan. Farshad.mansouri@monash.edu., Buckley MJ; Department of Experimental Psychology, Oxford University, Oxford, OX1 3UD, UK., Tanaka K; RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 140. Date of Electronic Publication: 2024 Jan 02.
DOI: 10.1038/s41467-023-44341-5
Abstrakt: Intra-individual behavioral variability is significantly heightened by aging or neuropsychological disorders, however it is unknown which brain regions are causally linked to such variabilities. We examine response time (RT) variability in 21 macaque monkeys performing a rule-guided decision-making task. In monkeys with selective-bilateral lesions in the anterior cingulate cortex (ACC) or in the dorsolateral prefrontal cortex, cognitive flexibility is impaired, but the RT variability is significantly diminished. Bilateral lesions within the frontopolar cortex or within the mid-dorsolateral prefrontal cortex, has no significant effect on cognitive flexibility or RT variability. In monkeys with lesions in the posterior cingulate cortex, the RT variability significantly increases without any deficit in cognitive flexibility. The effect of lesions in the orbitofrontal cortex (OFC) is unique in that it leads to deficits in cognitive flexibility and a significant increase in RT variability. Our findings indicate remarkable dissociations in contribution of frontal cortical regions to behavioral variability. They suggest that the altered variability in OFC-lesioned monkeys is related to deficits in assessing and accumulating evidence to inform a rule-guided decision, whereas in ACC-lesioned monkeys it results from a non-adaptive decrease in decision threshold and consequently immature impulsive responses.
(© 2024. The Author(s).)
Databáze: MEDLINE
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