Evaluation of the mannan antigen assay in neonates with or without Candida albicans colonization.

Autor:	Bourika V; Neonatal Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece., Siahanidou T; Neonatal Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece., Theodoridou K; Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Tsakris A; Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Vrioni G; Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Michos A; Division of Infectious Diseases, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Medical mycology [Med Mycol] 2024 Jan 27; Vol. 62 (2).
DOI:	10.1093/mmy/myad138
Abstrakt:	Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA (Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% specificity) and in 30/30 non-colonized neonates (100% specificity). The results indicate a high specificity of the assay, which could be useful in neonates with possible candidemia. (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
Databáze:	MEDLINE
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